Bioprobes : biochemical tools for investigating cell function
This new edition provides the most advanced research using bioprobes on the chemical control of 1) cell cycle and differentiation, 2) epigenetics, 3) apoptosis and autophagy, and 4) immune response. The "bioprobe", first proposed in the first edition, has become an indispensable tool for c...
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| Other Authors: | |
|---|---|
| Format: | eBook |
| Language: | English |
| Published: |
Tokyo :
Springer,
2017.
|
| Edition: | 2nd ed. |
| Subjects: | |
| ISBN: | 9784431565291 9784431565277 |
| Physical Description: | 1 online resource (387 pages) |
Cover
Table of contents
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| 245 | 0 | 0 | |a Bioprobes : |b biochemical tools for investigating cell function / |c Hiroyuki Osada, editor. |
| 250 | |a 2nd ed. | ||
| 260 | |a Tokyo : |b Springer, |c 2017. | ||
| 300 | |a 1 online resource (387 pages) | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a počítač |b c |2 rdamedia | ||
| 338 | |a online zdroj |b cr |2 rdacarrier | ||
| 505 | 0 | |a Preface; Contents; Chapter 1: Trends in Bioprobe Research; 1.1 Introduction; 1.2 Screening of New Bioactive Compounds; 1.2.1 Cell-Based Screening; 1.2.2 Target-Based Screening; 1.3 Target Identification of Bioactive Compounds; 1.3.1 Cell Morphology-Based Profiling; 1.3.2 Proteomic Profiling; 1.3.3 Affinity Beads; 1.3.4 DARTS and CESTA; 1.4 Trends and Prospects; References; Chapter 2: Cell Proliferation and Differentiation; 2.1 Cell Growth Signaling Pathway; 2.1.1 Growth Factors and Receptors; 2.1.1.1 EGF Receptors; 2.1.1.2 Ras-MAP Kinase Pathway. | |
| 505 | 8 | |a 2.1.2 Cytokine Receptors Without Kinase Domains; 2.1.3 Cell Adhesion Receptors; 2.1.4 Dysregulation of Signaling Pathways in Cancer Cells; 2.1.4.1 Bcr-Abl Oncoprotein; 2.1.4.2 Other Abl Fusion Genes in Cancer Cells; 2.1.4.3 Inhibitor of Bcr-Abl Fusion Gene Products; 2.1.4.4 EML4-ALK Oncoprotein; 2.1.4.5 Inhibitor of EML4-ALK Fusion Gene Products; 2.1.4.6 Drug-Resistant Mutation in ALK; 2.1.4.7 Other Fusion Protein Tyrosine Kinases; 2.2 Cell Cycle Regulation; 2.2.1 Cell Cycle Regulators; 2.2.2 Cyclins and CDKs; 2.2.2.1 Cyclin and CDKs; 2.2.2.2 CDKs; 2.2.2.3 Cyclins; 2.2.2.4 CDK Inhibitors. | |
| 505 | 8 | |a 2.2.3 M-Phase Kinases and Their Inhibitors; 2.2.3.1 Plk1; 2.2.3.2 Plk1 Inhibitors; 2.2.3.3 PBD-Dependent Binding Inhibitors; 2.2.3.4 Aurora Kinases; 2.2.3.5 Aurora Kinase Inhibitors; 2.2.3.6 First-Generation Inhibitors of Aurora Kinases; 2.2.3.7 Pan-Aurora Inhibitors; 2.2.3.8 Aurora A-Specific Inhibitors; 2.2.3.9 Aurora B-Specific Inhibitors; 2.3 Cell Differentiation; 2.3.1 iPS Cells; 2.3.2 iPS Cells Induced by Small-Molecule Compounds; 2.3.3 Medical Purposes; 2.3.4 Cancer Stem Cells; 2.3.5 Small Molecules that Target CSCs; References; Chapter 3: Epigenetics; 3.1 Introduction. | |
| 505 | 8 | |a 3.2 Histone Acetylation; 3.2.1 Histone Deacetylases; 3.2.2 Histone Deacetylase Inhibitors; 3.2.2.1 Zinc-Dependent Histone Deacetylase Inhibitors; 3.2.2.1.1 Carboxylates; 3.2.2.1.2 Hydroxamic Acids; 3.2.2.1.3 Anilides; 3.2.2.1.4 Cyclic Tetrapeptides; 3.2.2.1.5 Thiols; 3.2.2.1.6 Dietary Inhibitors; 3.2.2.2 Sirtuin Inhibitors; 3.2.2.2.1 NAD Analogs; 3.2.2.2.2 Nicotinamide and Its Analogs; 3.2.2.2.3 beta-Naphthol Analogs; 3.2.2.2.4 Indoles; 3.2.2.2.5 Other Sirtuin Inhibitors; 3.2.3 Histone Acetyltransferases; 3.2.4 Histone Acetyltransferases Inhibitors; 3.2.4.1 Natural Product Inhibitors. | |
| 505 | 8 | |a 3.2.4.2 Bisubstrate Inhibitors; 3.2.4.3 C646; 3.2.5 Bromodomain and Extraterminal Protein Inhibitors; 3.3 Histone Methylation; 3.3.1 Histone Methyltransferases; 3.3.2 Lys-Specific Histone Methyltransferase Inhibitors; 3.3.2.1 G9a Inhibitors; 3.3.2.2 EZH2 Inhibitors; 3.3.2.3 Dot1L Inhibitors; 3.3.3 Histone Demethylases; 3.3.4 Lysine Demethylases Inhibitors; 3.3.4.1 Lysine Specific Demethylase 1 Inhibitors; 3.3.4.2 Jumonji Domain-Containing Histone Demethylase Inhibitors; 3.4 DNA Methylation; 3.4.1 DNA Methyltransferase Inhibitors; 3.5 Conclusions; References; Chapter 4: Apoptosis and Autophagy; 4.1 Introduction. | |
| 504 | |a Includes bibliographical references and index. | ||
| 506 | |a Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty | ||
| 520 | |a This new edition provides the most advanced research using bioprobes on the chemical control of 1) cell cycle and differentiation, 2) epigenetics, 3) apoptosis and autophagy, and 4) immune response. The "bioprobe", first proposed in the first edition, has become an indispensable tool for chemical biology and has substantially assisted in the investigation of complex biochemical processes of cells. New areas of investigation such as stem cell research, epigenetic research, and autophagy research have rapidly advanced in the past 10 years. Including these new findings, this second edition supplies up-to-date information on the biochemical tools called bioprobes. Data on each bioprobe, such as chemical structure, origin, function, and references, are presented as one item in this volume. Readers will easily find useful information and will be able to determine the appropriate bioprobes to investigate cell functions. The information on bioprobes and their use in research makes this book a valuable source for researchers in diverse fields. Not only scientists in academia but also in the pharmaceutical industries will discover the most important information about small molecules useful for drug discovery. | ||
| 590 | |a SpringerLink |b Springer Complete eBooks | ||
| 650 | 0 | |a Molecular probes. | |
| 650 | 0 | |a Cytology |x Methodology. | |
| 655 | 7 | |a elektronické knihy |7 fd186907 |2 czenas | |
| 655 | 9 | |a electronic books |2 eczenas | |
| 700 | 1 | |a Osada, H. |q (Hiroyuki), |d 1954- | |
| 776 | 0 | 8 | |i Print version: |a Osada, Hiroyuki. |t Bioprobes : Biochemical Tools for Investigating Cell Function. |d Tokyo : Springer Japan, ©2017 |z 9784431565277 |
| 856 | 4 | 0 | |u https://proxy.k.utb.cz/login?url=https://link.springer.com/10.1007/978-4-431-56529-1 |y Plný text |
| 992 | |c NTK-SpringerBLS | ||
| 999 | |c 97317 |d 97317 | ||
| 993 | |x NEPOSILAT |y EIZ | ||
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