Cartilage. Volume 3, Repair strategies and regeneration /

• Other Authors: Grässel, Susanne (Editor), Aszódi, Attila (Editor)
• Format: Electronic eBook
• Language: English
• Published: Cham, Switzerland : Springer, 2017.
• Subjects: Cartilage.; Cartilage > Regeneration.; elektronické knihy; electronic books
• ISBN: 9783319533162; 9783319533148
• Physical Description: 1 online resource

In three Volumes this mini book series presents current knowledge and new perspectives on cartilage as a specialized yet versatile tissue. This third volume provides insight into current and future treatment strategies for repair of cartilage lesions. This book addresses Professors, researchers and...

Table of Contents:

• Preface; Contents; List of Contributors; 1: Overview: State of the Art and Future Prospectives for Cartilage Repair; 1.1 Introduction; 1.1.1 Clinical Relevance and Needs of Cartilage Repair; 1.2 Cartilage Structure, Function, and Injuries; 1.2.1 Cartilage Structure; 1.2.2 Cartilage Injury; 1.2.3 Clinical Outcomes of Treatments; 1.3 Current Cartilage Repair Strategies; 1.3.1 Palliative Approach: Arthroscopic Debridement/Lavage; 1.3.2 Intrinsic Repair: Bone Marrow Stimulation Technique-Abrasion, Drilling, and Microfracture.
• 1.3.3 Whole Tissue Transplantation: Osteochondral Graft Transplantation1.3.4 Tissue-Engineered Cartilage; 1.3.4.1 Autologous Chondrocyte Implantation/Transplantation (ACI/ ACT); 1.3.5 Total Joint Replacement; 1.4 New Strategies Under Investigation; 1.4.1 Cell-Based Therapies; 1.4.1.1 Stem Cells; Stem Cell Types Relevant to Cartilage Repair; Signaling Factors: Stem Cell Differentiation and Cell Phenotype Maintenance; 1.4.1.2 Allogeneic Chondrocytes; 1.4.2 Biomaterial Scaffolds for Cartilage Repair; 1.4.2.1 Current Biomaterials and 3D Scaffolds.
• 1.4.2.2 Major Concerns in Scaffold Design1.5 Unsolved Problems and Challenges in Cartilage Repair; 1.5.1 Tissue Integration; 1.5.2 Maintenance of Cell Phenotype; 1.5.3 Simplifying Surgical and Rehabilitation Procedures; 1.5.4 Prevention of OA Progress; 1.5.4.1 Establishing Correct Joint Mechanical Environment; 1.5.4.2 Rebuilding Subchondral Bone; 1.5.4.3 Anti-Inflammatory Actions; References; 2: MSC Populations for Cartilage Regeneration; 2.1 Embryonic Origin of Chondroprogenitor Cells (CPCs); 2.2 In Vivo Presence of MSCs in Adult Joints; 2.2.1 Characteristics of MSCs In Vivo.
• 2.2.1.1 Articular Cartilage-Derived Chondroprogenitor cells (CPCs)2.2.1.2 Bone Marrow-Derived MSCs (BMSCs); 2.2.1.3 Synovium-Derived MSCs (SM-MSCs); 2.2.1.4 Synovial Fluid-Derived MSCs (SF-MSCs); 2.2.1.5 Infrapatellar Fat Pad-Derived MSCs (IF-MSCs); 2.2.2 Contribution to Repair by MSCs In Vivo; 2.3 MSCs In Vitro; 2.3.1 Articular Cartilage-Derived MSCs (AC-MSCs); 2.3.2 Bone Marrow-Derived MSCs (BMSCs); 2.3.3 Synovium-Derived MSCs (SM-MSCs); 2.3.4 Synovial Fluid-Derived MSCs (SF-MSCs); 2.3.5 Infrapatellar Fat Pad-Derived MSCs (IF-MSCs).
• 2.4 Manipulation of Joint Stem Cell Phenotype In Vitro by Growth FactorsReferences; 3: Chondrogenic Progenitor Cells and Cartilage Repair; 3.1 Osteoarthritis and Rheumatoid Arthritis; 3.2 Regeneration Attempts in Cartilage Tissue; 3.2.1 Mesenchymal Stem Cells and Osteoarthritis; 3.2.2 Mesenchymal Stem Cells and Rheumatoid Arthritis; 3.3 Chondrogenic Progenitor Cells; 3.3.1 Chondrogenic Progenitor Cells from Osteoarthritic Patients (CPCs); 3.3.2 Chondrogenic Progenitor Cells from Rheumatoid Arthritis Patients; 3.3.3 Meniscus Progenitor Cells (MPCs); References.