Computational psychiatry : a systems biology approach to the epigenetics of mental disorders

• Main Author: Wallace, Rodrick (Author)
• Format: Electronic eBook
• Language: English
• Published: Cham, Switzerland : Springer, 2017.
• Subjects: Psychiatry.; Systems biology.; elektronické knihy; electronic books
• ISBN: 9783319539102; 9783319539096
• Physical Description: 1 online resource (xii, 236 pages) : illustrations

This book explores mental disorders from a uniquely evolutionary perspective. Although there have been many attempts to mathematically model neural processes and, to some extent, their dysfunction, there is very little literature that models mental function within a sociocultural, socioeconomic, and...

Table of Contents:

• Preface; Contents; 1 Consciousness, Crosstalk, and the Mereological Fallacy; 1.1 Introduction; 1.2 Some Cognitive Global Broadcasts; Immune System; Tumor Control; Wound Healing; Gene Expression; Sociocultural Cognition; 1.3 Animal Consciousness; 1.4 Cognition as ``Language''; 1.5 No Free Lunch; 1.6 Multiple Broadcasts, Punctuated Detection; 1.7 Metabolic Constraints; 1.8 Environmental Signals; 1.9 Dynamic ``Regression Models''; 1.10 Phase Transition Approaches; Basic Ideas; Kadanoff Theory; Other Versions of the Kadanoff Model; 1.11 The Rate Distortion Approach; Some Formalism; A Simple Model.
• A Less Simple ModelThe Index Theorem Attack; 1.12 Discussion and Conclusions; References; 2 Cultural Epigenetics: On the Missing Heritabilityof Complex Diseases; 2.1 Introduction; Mental Disorders and Culture; 2.2 A Cognitive Paradigm for Gene Expression; 2.3 Models of Development; 2.4 Tunable Epigenetic Catalysis; 2.5 The Groupoid Free Energy; Spontaneous Symmetry Breaking; The Groupoid Atlas; 2.6 ``Phase Change'' and the Developmental Holonomy Groupoid in Phenotype Space; 2.7 Holonomy on the Manifold of Dual Information Sources; Basic Structure; ``Coevolutionary'' Development.
• 2.8 Rate Distortion ModelsThe Rate Distortion Theorem; Rate Distortion Dynamics; Rate Distortion Coevolutionary Dynamics; 2.9 Expanding the Mathematical Approach; 2.10 Discussion; References; 3 Western Atomism and Its Culture-Bound Syndromes; 3.1 Introduction; 3.2 Western Atomistic Economics; 3.3 Cognition as an Information Source; 3.4 Environment as an Information Source; 3.5 Interacting Information Sources; 3.6 Crosstalk Topologies; 3.7 Punctuated Critical Phenomena; 3.8 Discussion and Conclusions; References; 4 Environmental Induction of Neurodevelopmental Disorders; 4.1 Introduction.
• 4.2 A Control Theory Model4.3 A ``Cognitive'' Model; 4.4 The Mitochondrial Connection; 4.5 Discussion and Conclusions; References; 5 Sleep, Psychopathology, and Culture; 5.1 Introduction; 5.2 Reaction Rate; 5.3 The Data Rate Theorem; 5.4 Rate Distortion Dynamics; 5.5 The Sleep Cycle: An Optimization Model; 5.6 Transition Dynamics; 5.7 Cultural Catalysis of the Sleep Cycle; 5.8 Environmental Induction of Sleep Disorders; 5.9 Chronic Dysfunctions of the Sleep Cycle; 5.10 Discussion and Conclusions; References; 6 Embodied Cognition and Its Disorders; 6.1 Introduction; 6.2 The Data Rate Theorem.
• 6.3 Cognition as an Information Source6.4 Environment as an Information Source; 6.5 Body Dynamics and Culture as Information Sources; 6.6 Interacting Information Sources; 6.7 Simple Regulation; 6.8 Extending the Data Rate Theorem; 6.9 Another Picture; 6.10 Large Deviations and Epileptiform Disorders; 6.11 Ground State Collapse 1: Anxiety/Depression Analogs; 6.12 Ground State Collapse 2: Obsessive Compulsive Disorders; 6.13 Topological Dysfunctions: Autism Spectrum and Schizophreniform Analogs; 6.14 Discussion and Conclusions; References; 7 Tools for the Future: Hidden Symmetries.