Adipose tissue biology

• Other Authors: Symonds, Michael E., 1960- (Editor)
• Format: Electronic eBook
• Language: English
• Published: New York : Springer, [2017]
• Edition: Second edition.
• Subjects: Adipose tissues.; elektronické knihy; electronic books
• ISBN: 9783319520315; 9783319520292
• Physical Description: 1 online resource : illustrations

The past decade has seen an exponential increase in our knowledge and understanding of adipose tissue biology. This has coincided with the continued rise in obesity across all generations. Clearly despite substantial advances in research into adipose tissue this still has had limited impact on the o...

Table of Contents:

• Chapter 1: The Evolution of€Mammalian Adipose Tissues; 1.1 Introduction; 1.1.1 Comparative Perspectives on€Obesity and€Diabetes; 1.2 Storage Tissues; 1.2.1 Invertebrates; 1.2.2 Vertebrate Adipose Tissues; 1.2.3 Fish, Amphibians and€Reptiles; 1.3 White Adipose Tissue in€Mammals and€Birds; 1.3.1 Anatomical Distribution and€Site-Specific Properties; 1.3.2 Cellular Structure of€Adipose Tissue; 1.3.3 Structural Adipose Tissue; 1.4 Brown and€Beige Adipose Tissue; 1.4.1 Origins of€Thermogenic Mechanisms; 1.5 The Specificity of€Fatty Acids; 1.5.1 Structural Lipids.
• 1.5.2 Storage Lipids as€Fuels1.5.3 Fatty Acid Sorting; 1.6 Paracrine Interactions with€Adipose Tissue; 1.6.1 The Immune System; 1.6.2 Perinodal Adipose Tissue Around Lymph Nodes; 1.6.3 Permeating Dendritic Cells; 1.6.4 Adipose Tissue in€Normal Immune Function; 1.6.5 Human Perinodal Adipose Tissue; 1.6.6 Paracrine Interactions with€Muscle; 1.6.7 Cardiac Adipose Tissues; 1.6.8 Perivascular Adipose Tissue; 1.7 Adipose Tissues for€Mammalian Habits and€Habitats; 1.7.1 Diet; 1.7.2 Controlled Heterothermy and€Thermogenesis; 1.7.3 Pregnancy and€Lactation.
• 1.7.4 Primates and€the€Origins of€Human Obesity1.7.5 Rapid Adaptation to€Modern Diets and€Lifestyles; 1.8 Conclusions; References; Chapter 2: Adipocyte Progenitors from€Human Pluripotent Stem Cells; 2.1 Introduction; 2.2 Potential of€Human PSCs to€Generate Adipocytes; 2.3 Adipogenic Capacity of€hPSC-Derived Adipocyte Progenitors; 2.4 Developmental Origins of€Human Brown Adipocyte Progenitors; References; Chapter 3: Adipocyte Differentiation; 3.1 Introduction; 3.2 In Vitro Experimental Systems to Study Adipocyte Differentiation; 3.2.1 Preadipocyte Cell Lines.
• 3.2.2 Mature Adipocyte-Derived Dedifferentiated Fat Cells3.2.3 Mesenchymal Stem Cells; 3.2.4 Adipose-Derived Stem Cells (ADSCs); 3.3 Stages of Adipocyte Differentiation; 3.4 Nuclear Regulation of Adipocyte Differentiation; 3.4.1 Transcriptional Regulation of Adipocyte Differentiation; 3.4.2 Transcriptional Cofactors in Adipogenesis; 3.5 Extranuclear Regulation of Adipocyte Differentiation; 3.5.1 Adipogenic Factors; 3.5.2 Antiadipogenic Factors; 3.5.3 Other Players in the Regulation of Adipogenesis; 3.5.3.1 Epigenetic Factors in Adipogenesis; 3.5.3.2 The Role of miRNAs in Adipogenesis.
• 3.5.3.3 Chronobiology in Adipogenesis3.6 Future Perspectives; References; Chapter 4: Brown Adipose Tissue; 4.1 Biological Significance of€Brown Adipose Tissue; 4.2 Anatomy and€Innervation; 4.3 Molecular Mechanism of€Thermogenesis in€Brown Adipose Tissue; 4.3.1 Mitochondrial Bioenergetics; 4.3.2 UCP1 as€a€Catalyst of€Uncoupled Respiration in€Brown Adipocytes; 4.3.3 Mode of€UCP1 Action; 4.4 Activation of€Brown Adipose Tissue; 4.4.1 The Central POA-DMH-rPAa Axis Controls Acute Brown Adipose Tissue Thermogenesis; 4.4.2 Neuroendocrine Stimulation of€Diet-Induced BAT Thermogenesis.