Squamous cell carcinoma : molecular therapeutic targets

This edited volume is about novel targeted therapies for the treatment of advanced neoplasms of the head and neck (HNSCC) with particular reference to oral squamous cell carcinomas and covers specific fields of cancer genetics and genomics for personalized medicine. The landmark studies from the HNS...

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Bibliographic Details
Other Authors: Warnakulasuriya, S. (Editor), Khan, Zakir, 1979- (Editor)
Format: eBook
Language: English
Published: Dordrecht, Netherlands : Springer, 2017.
Subjects:
Squamous cell carcinoma.
elektronické knihy
electronic books
ISBN: 9789402410846
9789402410839
Physical Description: 1 online resource : illustrations

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245 0 0 |a Squamous cell carcinoma :  |b molecular therapeutic targets /  |c Saman Warnakulasuriya, Zakir Khan, editors. 
264 1 |a Dordrecht, Netherlands :  |b Springer,  |c 2017. 
300 |a 1 online resource :  |b illustrations 
336 |a text  |b txt  |2 rdacontent 
337 |a počítač  |b c  |2 rdamedia 
338 |a online zdroj  |b cr  |2 rdacarrier 
500 |a Includes index. 
506 |a Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty 
520 |a This edited volume is about novel targeted therapies for the treatment of advanced neoplasms of the head and neck (HNSCC) with particular reference to oral squamous cell carcinomas and covers specific fields of cancer genetics and genomics for personalized medicine. The landmark studies from the HNSCC Cancer Genome Anatomy (TCGA) and the cancer Genome Atlas 2015 have revealed the multiplicity and diversity of genetic alterations in HNSCC. This remarkable body of information has elucidated novel druggable targets (eg. EGFR, mTOR, p53, survivin and aberrant microRNA) for therapeutic interventions in head and neck cancer. Readers will discover the importance of the biology and pathology of squamous cell carcinomas, the role of cancer stem cells and other factors that contribute to resistance to curative therapies such as hypoxia. We present an in-depth analysis of the HNSCC oncogenome describing the distinct molecular alterations in squamous cell carcinomas, which participate in specific molecular pathways whose dysregulation may contribute to most HNSCC cases. Final chapters of the book elucidate how these important cancer-driving molecular events and molecular pathways could be targeted to treat head and neck cancers and their therapeutic applications for targeted therapies based on clinical trials reported worldwide. This book is aimed at a broad audience, including scientists, physicians, surgeons, and post graduate students engaged in oncology and provide the readers with an up-to-date, interdisciplinary knowledge and tools to better understand the evolving areas of targeted gene therapy and the key concept of personalized medicine in head and neck cancer. 
505 0 |a Preface -- Foreword.-Introduction- The biology and pathology of squamous cell carcinomata in the head and neck -- Cancer Stem Cells -- Biopathology with reference to Head & Neck Cancers -- Hypoxia in head and neck cancer -- Genetic aberrations and molecular pathways in head and neck cancer -- p53 in Head and Neck Squamous Cell Carcinoma -- Blockage of EGFR pathway for anticancer therapy in squamous cell carcinoma of the head and neck -- Targeting the mTOR signaling circuitry in head and neck cancer -- Survivin as a Therapeutic Target in Squamous Cell Carcinoma -- MicroRNA: utility as biomarkers and therapeutic targets in squamous cell carcinoma -- Envoi -- An appraisal of Targeted Therapies for Head and Neck Cancer -- Index. 
590 |a SpringerLink  |b Springer Complete eBooks 
650 0 |a Squamous cell carcinoma. 
655 7 |a elektronické knihy  |7 fd186907  |2 czenas 
655 9 |a electronic books  |2 eczenas 
700 1 |a Warnakulasuriya, S.  |q (Saman),  |e editor. 
700 1 |a Khan, Zakir,  |d 1979-  |e editor. 
776 0 8 |i Print version:  |t Squamous cell carcinoma.  |d Dordrecht, Netherlands : Springer, 2017  |z 940241083X  |z 9789402410839  |w (OCoLC)968758493 
856 4 0 |u https://proxy.k.utb.cz/login?url=https://link.springer.com/10.1007/978-94-024-1084-6  |y Plný text 
992 |c NTK-SpringerBLS 
999 |c 97253  |d 97253 
993 |x NEPOSILAT  |y EIZ 

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