rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Proteomic methods in neuropsychiatric research
  name:
    name part: Guest, Paul C.
    role:
      role term: editor.
  type of resource: text
  genre: bibliography
  genre: elektronické knihy
  genre: electronic books
  origin info:
    place:
      place term: sz
    date issued: 2017
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource : illlustrations
  abstract: Due to continuous technical developments and new insights into the high complexity of neurological diseases, there is an increasing need for the application of proteomic technologies which can yield potential biomarker readouts for improved clinical management as well as for the development of new drugs by struggling pharmaceutical companies. This book describes the step-by-step use of proteomic methods such as two-dimensional gel electrophoresis, multiplex immunoassay, liquid chromatography mass spectrometry (LC-MS) and selective reaction monitoring MS, to increase our understanding of these diseases, with the ultimate aim of improving patient care. The volume will be of high interest to clinical scientists, physicians and pharmaceutical company scientists as it gives insights into the latest technologies enabling the revolution of personalized medicine. It is of direct interest to both technical and bench biomarker scientists as it gives step by step instructions on how to carry out each of the protocols. It is also of interest to researchers as each technique will be presented in the context of a specific neurological disorder, including Alzheimer's disease, multiple sclerosis, autism spectrum disorders, schizophrenia, major depressive disorder and bipolar disorder. Finally, it will also highlight the future research efforts in this field, which are endeavoring to convert proteomic platforms to the form of hand held devices which can be used in a point of care setting and return diagnostic results within the timeframe of a visit to the general practitioner.
  table of contents: Preface -- Proteomic studies in psychiatric disease and neurological disorders -- Part 1: REVIEWS -- Application of proteomic techniques for improved stratification and treatment of schizophrenia patients -- Multiplexing biomarker methods, proteomics and considerations for Alzheimer's disease -- What have proteomic studies taught us about novel drug targets in autism? -- Application of proteomic approaches to accelerate drug development for psychiatric disorders -- Proteomic biomarker identification in cerebrospinal fluid for leptomeningeal metastases with neurological complications -- Connecting brain proteomics with behavioural neuroscience in translational animal models of neuropsychiatric disorders -- LC-MSE for qualitative and quantitative proteomicstudies of psychiatric disorders -- The utility of multiplex assays for identification of proteomic signatures in psychiatry -- Part 2: PROTOCOLS -- Blood sampling and preparation procedures for proteomic biomarker studies of psychiatric disorders -- Multiplex immunoassay profiling of serum in psychiatric disorders -- Sequential immunopreciptation of secretory vesicle proteins from biosynthetically-labelled cells -- 2d gel electrophoresis of insulin secretory granule proteins from biosynthetically-labelled pancreatic islets -- Two-dimensional gel electrophoresis: a reference protocol -- A two-dimensional difference gel electrophoresis (2D-DIGE) protocol for studies of neural precursor cells -- Identifying biomarker candidates in the blood plasma or serum proteome -- Selective reaction monitoring mass spectrometry for quantitation of glycolytic enzymes in post-mortem brain samples -- A selected reaction monitoring mass spectrometry protocol for validation of proteomic biomarker candidates in studies of psychiatric disorders -- Application of iTRAQ shotgun proteomics for measurement of brain proteins in studies of psychiatric disorders -- Co-immunoprecipitation for deciphering protein interactomes -- Sequential co-immu…
  note: Paul C. Guest, editor.
  note: Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty
  note: Includes bibliographical references.
  subject:
    topic: Neuropsychiatry
    topic: Research
    topic: Methodology
  subject:
    topic: Proteomics
  subject:
    topic: Biochemical markers
  related item:
    title info:
      title: Proteomic methods in neuropsychiatric research
    origin info:
      publisher: Cham, Switzerland : Springer, [2017]
    identifier: (DLC) 2017935365
    identifier: (OCoLC)989068730
  related item:
    title info:
      title: Advances in experimental medicine and biology ; v. 974
  related item:
    title info:
      title: Advances in experimental medicine and biology
      part name: Proteomics, metabolomics, interactomics and systems biology
  identifier: 9783319524795
  identifier: 9783319524788
  identifier: https://proxy.k.utb.cz/login
  access condition: Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty
  record info:
    record content source: N$T
    record creation date: 170403
    record change date: 20251008101050.0
    record identifier: 97248
    language of cataloging:
      language term: eng