Leucine-Rich Repeat kinase 2 (LRRK2)

This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology,...

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Bibliographic Details
Other Authors Rideout, Hardy J. (Editor)
Format Electronic eBook
LanguageEnglish
Published Cham, Switzerland : Springer, [2017]
SeriesAdvances in neurobiology ; 14.
Subjects
Neurogenetics.
Chromosomes.
Parkinson's disease > Genetic aspects.
elektronické knihy
electronic books
Online AccessFull text
ISBN9783319499697
9783319499673
Physical Description1 online resource

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Table of Contents:
  • Part I: Clinical and Genetic Considerations of LRRK2 Associated Parkinson's Disease
  • Leucine-rich repeat kinase (LRRK2) genetics and Parkinson's disease
  • Clinical features of LRRK2 carriers with Parkinson's disease
  • Part II: Fundamentals of LRRK2 Biology
  • LRRK2 phosphorylation
  • Understanding the GTPase activity of LRRK2: regulation, function and neurotoxicity
  • LRRK2 and autophagy
  • Molecular insights and functional implication of LRRK2 dimerization
  • LRRK2 and the immune system
  • Regulation of LRRK2 by phosphatases
  • Part III: LRRK2 Neurodegeneration, Modeling, and Therapeutic Options
  • Animal models of LRRK2-associated Parkinson's disease
  • LRRK2 and the?LRRKtosome? at the crossroads of programmed cell death: Clues from RIP kinase relatives
  • Interaction of LRRK2 and?-synuclein in Parkinson's disease
  • Mechanisms of mutant LRRK2 neurodegeneration
  • Small molecule inhibitors of LRRK2.

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