Leucine-Rich Repeat kinase 2 (LRRK2)

This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology,...

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Bibliographic Details
Other Authors: Rideout, Hardy J., (Editor)
Format: eBook
Language: English
Published: Cham, Switzerland : Springer, [2017]
Series: Advances in neurobiology ; 14.
Subjects:
Neurogenetics.
Chromosomes.
Parkinson's disease > Genetic aspects.
elektronické knihy
electronic books
ISBN: 9783319499697
9783319499673
Physical Description: 1 online resource

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Table of contents

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020 |a 9783319499697  |q (electronic bk.) 
020 |z 9783319499673 
024 7 |a 10.1007/978-3-319-49969-7  |2 doi 
035 |a (OCoLC)980874356  |z (OCoLC)981708571  |z (OCoLC)981852355  |z (OCoLC)984854372  |z (OCoLC)999481197  |z (OCoLC)1005772395  |z (OCoLC)1012074520  |z (OCoLC)1048114338  |z (OCoLC)1058371211  |z (OCoLC)1066460067  |z (OCoLC)1097138896  |z (OCoLC)1112508876 
245 0 0 |a Leucine-Rich Repeat kinase 2 (LRRK2) /  |c Hardy J. Rideout, editor. 
264 1 |a Cham, Switzerland :  |b Springer,  |c [2017] 
300 |a 1 online resource 
336 |a text  |b txt  |2 rdacontent 
337 |a počítač  |b c  |2 rdamedia 
338 |a online zdroj  |b cr  |2 rdacarrier 
490 1 |a Advances in neurobiology ;  |v volume 14 
504 |a Includes bibliographical references. 
506 |a Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty 
520 |a This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration. 
505 0 |a Part I: Clinical and Genetic Considerations of LRRK2 Associated Parkinson's Disease -- Leucine-rich repeat kinase (LRRK2) genetics and Parkinson's disease -- Clinical features of LRRK2 carriers with Parkinson's disease -- Part II: Fundamentals of LRRK2 Biology -- LRRK2 phosphorylation -- Understanding the GTPase activity of LRRK2: regulation, function and neurotoxicity -- LRRK2 and autophagy -- Molecular insights and functional implication of LRRK2 dimerization -- LRRK2 and the immune system -- Regulation of LRRK2 by phosphatases -- Part III: LRRK2 Neurodegeneration, Modeling, and Therapeutic Options -- Animal models of LRRK2-associated Parkinson's disease -- LRRK2 and the?LRRKtosome? at the crossroads of programmed cell death: Clues from RIP kinase relatives -- Interaction of LRRK2 and?-synuclein in Parkinson's disease -- Mechanisms of mutant LRRK2 neurodegeneration -- Small molecule inhibitors of LRRK2. 
590 |a SpringerLink  |b Springer Complete eBooks 
650 0 |a Neurogenetics. 
650 0 |a Chromosomes. 
650 0 |a Parkinson's disease  |x Genetic aspects. 
655 7 |a elektronické knihy  |7 fd186907  |2 czenas 
655 9 |a electronic books  |2 eczenas 
700 1 |a Rideout, Hardy J.,  |e editor. 
776 0 8 |i Print version:  |t Leucine-Rich Repeat kinase 2 (LRRK2).  |d Cham, Switzerland : Springer, [2017]  |z 331949967X  |z 9783319499673  |w (OCoLC)961415076 
830 0 |a Advances in neurobiology ;  |v 14. 
856 4 0 |u https://proxy.k.utb.cz/login?url=https://link.springer.com/10.1007/978-3-319-49969-7  |y Plný text 
992 |c NTK-SpringerBLS 
999 |c 97247  |d 97247 
993 |x NEPOSILAT  |y EIZ 

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