http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
Drug resistance in bacteria, fungi, malaria, and cancer
This book is a compilation of past and recent knowledge in the field of emerging drug resistance. The book covers major aspects of drug resistance in bacteria, fungi, malaria, and cancer. Human survival on earth is constantly threatened by disease and syndrome. From the early days, the aim of research in medicine was to find therapeutic agents that can improve the quality of human life. Although humans are dependent on natural compounds from early days their dependence of drugs increased excessively in last century. The advances in chemistry and biology have helped researchers to identify the drugs that have improved treatment of many diseases. The primary factor for treatment of these diseases is dependent on the efficacy of drugs available. The development of resistance to these drugs is one of the major hindrances. Although there are number of books available on this topic, drug resistance biology across kingdoms has never been discussed in a coherent way.
Preface; Contents; Author Biographies; Emerging Themes in Drug Resistance; 1 Pharmacogenomics; 1.1 Introduction; 1.2 Role of Pharmacogenomics in Drug Resistance; 1.2.1 Tuberculosis; 1.2.2 Epilepsy; 1.2.3 HIV; 1.3 Role of Pharmacogenomics in Drug Discovery; 2 Therapeutic Antibodies for Bacterial Diseases; 2.1 The Growing Problem of Antimicrobial Resistance; 2.2 The Need for New Therapeutic Interventions; 2.3 The Foundations of Antibody Therapy; 2.4 Antibody Structure; 2.5 Types of Therapeutic Antibody Molecules; 2.6 Clinical Pipeline; 2.6.1 Neutralization of Viruses and Toxins.
2.6.2 Opsonophagocytic Killing2.6.3 Complement Activation; 2.6.4 Antibody-Drug Conjugates; 2.7 Advantages and Disadvantages of Antibody Therapy; 3 Development of Drug Resistance Through Inter- and Intracellular Communication; 4 Exosome-Mediated Drug Resistance; 4.1 Extracellular Vesicles as Carriers of Drug-Resistant Traits Across Pathologies; 4.2 Vesicle-Mediated Drug Resistance in Noncommunicable Disorders; 4.3 Vesicle-Mediated Drug Resistance in Pathogenic Disorders; 5 Structuromics; 5.1 Role of Structuromics in Deciphering the Drug Resistance Mechanism.
5.2 Role of Structuromics in Drug Designing6 Posttranslationally Modified Protein Networks as Drug Targets; 7 Conclusions; References; Molecular Mechanism of Drug Resistance: Common Themes; 1 Introduction; 2 Mechanisms of Drug Resistance; 2.1 Intrinsic Resistance; 2.2 Acquired Resistance; 2.2.1 Diminution of Intracellular Antibiotic Load: The External Affairs; 2.2.1.1 Reducing Permeability: The Consular Affairs; 2.2.1.2 Enhancing the Efflux: The Deporting Mechanisms; 2.2.2 Modification of the Target: The Blacking Out; 2.2.2.1 Mutation of the Target.
2.2.2.2 Protection or Modification of the Target2.2.3 Neutralization of the Antibiotic: Warhead Destruction; 2.2.3.1 Hydrolytic Cleavage of the Antibiotic; 2.2.3.2 Addition of Functional Group; 3 Multi-, Extreme- and Pan-Drug Resistance: The Current Threats; 4 Conclusions and Future Perspectives; References; Molecular Mechanism of Drug Resistance; 1 Introduction; 2 Emergence of Drug Resistance: The Road So Far; 2.1 History of Antibiotic Resistance Development: A Problem Getting Worse; 3 Factors for Drug Resistance Development: The Ongoing Phenomena; 4 General Mechanism of Drug Resistance.
4.1 Intrinsic Resistance4.2 Acquired Resistance; 5 Drug Resistance Mechanism (Disease Specific); 5.1 Tumor Drug Resistance: An Evolving Paradigm; 5.2 Antibiotic Resistance: The Bacterial Weapons; 5.2.1 Survival Strategies; 5.2.2 Antibiotic Efflux Pump System; 5.2.3 Degradation of Antibiotic; 5.2.4 Alteration of Bacterial Target; 5.3 Tuberculosis: The Unsolved Puzzle; 5.4 Antifungal Drug Resistance; 5.4.1 Antifungal Agents and Their Mechanism of Action; 5.4.2 Ergosterol Biosynthesis Inhibitors (Azoles and Triazoles); 5.4.3 Polyenes; 5.4.4 5-Fluorocytosine: Nucleic Acid Synthesis Inhibitors.
Gunjan Arora, Andaleeb Sajid, Vipin Chandra Kalia, editors.
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