Sigma receptors : their role in disease and as therapeutic targets

• Other Authors: Smith, Sylvia B., (Editor), Su, Tsung-Ping, (Editor)
• Format: eBook
• Language: English
• Published: Cham, Switzerland : Springer, [2017]
• Series: Advances in experimental medicine and biology ; v. 964.
• Subjects: Nervous system > Degeneration.; Sigma receptors.; elektronické knihy; electronic books
• ISBN: 9783319501741; 9783319501727
• Physical Description: 1 online resource (xiii, 312 pages) : illustrations (chiefly color)
• ISSN: 2214-8019
• Access: Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty

"Originally confused with opioid receptors and then orphan receptors with no biological function, Sigma Receptors are now recognized as relevant to many degenerative diseases with remarkable potential as therapeutic targets. In this text, new information about the structure of sigma 1 receptor, its binding sites are provided as well as its expression in many cell types. It's putative role in degenerative neuronal diseases including amyotrophic lateral sclerosis, Alzheimer's disease, Parkinson's disease, Huntington's disease, pain, drug addiction and locomotor activity. Their roles in possible treatments for blinding retinal diseases emphasize the tremendous far-reaching potential for ligands for these receptors. Exciting breakthroughs in this dynamic field in the last decade are reported herein, which will guide future investigators in determining the full potential of this unique, yet abundantly expressed protein"--Publisher's description.