Blue biotechnology : from gene to bioactive product

• Other Authors: Müller, Werner E. G. (Editor), Schröder, Heinz C. (Editor), Wang, Xiaohong, Professor Dr (Editor)
• Format: Electronic eBook
• Language: English
• Published: Cham, Switzerland : Springer, 2017.
• Series: Progress in molecular and subcellular biology. Marine molecular biotechnology ; v. 55.
• Subjects: Marine biotechnology.; elektronické knihy; electronic books
• ISBN: 9783319512846; 9783319512822
• ISSN: 0079-6484 ;
• Physical Description: 1 online resource

This book describes the discovery of molecules from unexploited extreme marine environments, and presents new approaches in marine genomics. It combines the current state of knowledge in marine genomics and advanced natural products chemistry to pursue the sustainable production of novel secondary m...

Table of Contents:

• Preface; Contents; Contributors; 1 35 Years of Marine Natural Product Research in Sweden: Cool Molecules and Models from Cold Waters; Abstract; 1 Natural Product Research; 2 Marine Natural Product Research, a Field on the Rise; 3 Cold Waters, from the Shallow to the Deep; 4 Swedish Cold Waters; 5 The Emergence of Marine Pharmacognosy in Sweden; 6 Discovery of the Barettins from the Deep-Sea Sponge Geodia barretti; 7 Geodia barretti-A Sponge Model for Sponge Ground Investigations; 8 Cold-Water Temperatures Still Produce Cool Chemistry; 9 Interpretation, Prediction and Selection; 10 Conclusion.
• AcknowledgementsReferences; 2 Major Antimicrobial Representatives from Marine Sponges and/or Their Associated Bacteria; Abstract; 1 Introduction; 2 Antimicrobial Compounds from Marine Sponges; 2.1 Lipids; 2.2 Polyketides; 2.3 Steroids; 2.4 Terpenoids; 2.5 Alkaloids; 2.6 Peptides; 2.7 Miscellaneous Brominated Derivatives; 3 Antimicrobial Compounds from Sponge-Associated Bacteria; 4 Conclusions and Future Challenges; Bibliography; 3 Discovery and Development of Novel Drugs; Abstract; 1 Introduction; 2 Project Planning Phase; 3 Where to Start?; 4 Drug Discovery.
• 4.1 Chemical Tactics-Where to Get First Hits?4.2 Biological Tactics-Screening Cascade; 5 Drug Development; 6 Preclinical Development; 7 Clinical Development; 8 Non-clinical Development; References; 4 Computer-Aided Drug Discovery from Marine Compounds: Identification of the Three-Dimensional Structural Features Responsible for Antimalarial Activity; Abstract; 1 Introduction; 2 Materials and Methods: Molecular Modeling Studies; 3 Identification of the Three-Dimensional Structural Features Responsible for the Antimalarial Activity; 3.1 First Series of New Synthetic Analogues of Plakortin.
• 3.2 Second Series of New Synthetic Analogues of Plakortin3.3 New Natural Polyketide Endoperoxides; 3.4 Synthetic Analogs of Aplidinone A and B; 4 Conclusion; Acknowledgments; References; 5 Bluegenics: Bioactive Natural Products of Medicinal Relevance and Approaches to Their Diversification; Abstract; 1 History of Natural Products in Medicine; 2 The Role of Natural Products in Nature; 3 The Antibiotic Crisis and the Need for New Medicine; 4 Antibiotic Resistance; 5 Natural Products and the Clinic. Towards New Antibiotics in the Battle Against Resistance.
• 6 A Growing Focus on Marine Natural Products7 Generating Natural Product Analogues; 7.1 Total Synthesis; 7.2 Semisynthesis; 7.3 Precursor-Directed Biosynthesis; 7.4 Mutasynthesis; 7.5 Combinatorial Biosynthesis; 7.6 Genochemetics: gene expression enabling synthetic diversification; 8 Concluding Remarks and Future Perspective; References; 6 New Target Sites for Treatment of Osteoporosis; Abstract; 1 Introduction; 2 Osteoporosis; 3 Bone Remodeling; 4 Drug Therapy/Treatment of Osteoporosis; 4.1 Hormone-Replacement Therapies; 4.2 Bisphosphonates; 4.3 New Therapies for Osteoporosis.