Molecular pathogenesis and signal transduction by helicobacter pylori

This volume reviews the current state of research concerning bacterial virulence factors and the infection biology of Helicobacter pylori, which is the leading cause of peptic ulcers and gastric cancer worldwide. The chapters include cutting-edge findings on this fascinating microbe and discuss the...

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Bibliographic Details
Other Authors: Tegtmeyer, Nicole, (Editor), Backert, Steffen, (Editor)
Format: eBook
Language: English
Published: Cham, Switzerland : Springer, 2017.
Series: Current topics in microbiology and immunology ; 400.
Subjects:
Helicobacter pylori infections > Pathogenesis.
Pathology, Molecular.
elektronické knihy
electronic books
ISBN: 9783319505206
9783319505190
Physical Description: 1 online resource

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040 |a YDX  |b eng  |e pn  |c YDX  |d N$T  |d GW5XE  |d IDEBK  |d COO  |d OCLCQ  |d NJR  |d N$T  |d EBLCP  |d UPM  |d UAB  |d OCLCO  |d MERUC  |d IOG  |d OCLCO  |d ESU  |d OCLCO  |d MERER  |d OCLCO  |d JBG  |d IAD  |d OCLCO  |d ICW  |d OCLCO  |d ICN  |d OCLCQ  |d OCLCO  |d OTZ  |d OCLCO  |d OCLCQ  |d VT2  |d OCLCQ  |d OCLCO  |d OCLCQ  |d JG0  |d OCLCO  |d U3W  |d OCLCO  |d OCLCQ  |d OCLCO  |d OCLCQ  |d OCLCO  |d CAUOI  |d OCLCO  |d OCLCQ  |d OCLCO  |d OCLCF  |d OCLCO  |d OCLCQ  |d KSU  |d OCLCQ  |d OCLCO  |d OCLCQ  |d OCLCO  |d WYU  |d OCLCA  |d AU@  |d OCLCO  |d UKAHL  |d OCLCQ  |d OCLCA  |d OCLCQ  |d SFB 
020 |a 9783319505206  |q (electronic bk.) 
020 |z 9783319505190  |q (print) 
024 7 |a 10.1007/978-3-319-50520-6  |2 doi 
035 |a (OCoLC)970781788  |z (OCoLC)970393477  |z (OCoLC)971031210  |z (OCoLC)971091439  |z (OCoLC)971230449  |z (OCoLC)971357114  |z (OCoLC)971365118  |z (OCoLC)971521501  |z (OCoLC)974650098  |z (OCoLC)981775813  |z (OCoLC)994454567  |z (OCoLC)1004761954  |z (OCoLC)1005787728  |z (OCoLC)1011849659  |z (OCoLC)1155929126 
245 0 0 |a Molecular pathogenesis and signal transduction by helicobacter pylori /  |c Nicole Tegtmeyer, Steffen Backert, editors. 
260 |a Cham, Switzerland :  |b Springer,  |c 2017. 
300 |a 1 online resource 
336 |a text  |b txt  |2 rdacontent 
337 |a počítač  |b c  |2 rdamedia 
338 |a online zdroj  |b cr  |2 rdacarrier 
490 1 |a Current topics in microbiology and immunology ;  |v volume 400 
506 |a Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty 
520 |a This volume reviews the current state of research concerning bacterial virulence factors and the infection biology of Helicobacter pylori, which is the leading cause of peptic ulcers and gastric cancer worldwide. The chapters include cutting-edge findings on this fascinating microbe and discuss the general strategies of H. pylori infection and persistence, news on important H. pylori virulence factors, crosstalk with the microbiota, hot novel models and signaling mechanisms, risk factors of gastric disease and stomach cancer, and the impact of H. pylori infection on non-gastric diseases. Written by internationally respected scientists, this book will appeal to clinicians, researchers and advanced students alike. 
505 0 |a Foreword; Preface; Contents; Abbreviations; 1 The Human Stomach in Health and Disease: Infection Strategies by Helicobacter pylori; Abstract; 1 Introduction; 2 H. pylori Infection and Strategies of Persistence; 3 H. pylori Infection in Health and Disease; 3.1 Gastritis; 3.2 Peptic Ulcer Disease; 3.3 Gastric Adenocarcinoma; 3.4 MALT Lymphoma; 4 H. pylori Virulence Factors and their Association with Disease; 4.1 The cag Pathogenicity Island; 4.2 Vacuolating Cytotoxin (VacA); 4.3 DupA and tfs4; 4.4 NapA; 4.5 Adhesins; 5 Environmental Factors and their Association with Disease. 
505 8 |a 6 Treatment of H. pylori and Prospects for a Vaccine7 Concluding Remarks; Acknowledgements; References; 2 Human and Helicobacter pylori Interactions Determine the Outcome of Gastric Diseases; Abstract; 1 Helicobacter pylori: From Infection to Diseases; 2 The Chemokine CXCL8; 2.1 Induction of CXCL8 by H. pylori; 2.2 CXCL8 Gene Polymorphisms; 3 Induction and Role of ROS; 3.1 ROS During H. pylori Infection; 3.2 Expression and Role of NOX1; 3.3 Expression and Role of NOX2; 3.4 Expression and Role of SMOX; 3.5 Epigenetic Regulation of SMOX; 4 Nitrosative Stress; 4.1 H. pylori Infection and NOS2. 
505 8 |a 4.2 NO-Mediated H. pylori Carcinogenesis4.3 NOS2 Polymorphisms; 5 The Host and Bacteria Coevolution: The Crystal Ball of H. pylori Pathogenesis?; 6 Concluding Remarks; References; 3 Immune Evasion Strategies and Persistence of Helicobacter pylori; Abstract; 1 Introduction; 2 Innate Immune Evasion Strategies of H. pylori; 2.1 Evasion and Manipulation of Pattern Recognition Receptors; 2.1.1 Evasion of TLR Recognition and Manipulation of TLR-Mediated Signaling; 2.1.2 Inhibition of CLR-Mediated Signaling; 2.2 Inhibition of Phagocytosis and Killing by Reactive Oxygen Species and Nitric Oxide. 
505 8 |a 2.3 Inhibition of Antimicrobial Peptides3 Immune Tolerance Driven by H. pylori Interaction with Dendritic Cells; 4 Manipulation and Inhibition of Effector T Cell Responses; 5 Bacterial Plasticity and Immune Evasion; 6 Concluding Remarks; References; 4 Recent Advances in Helicobacter pylori Replication: Possible Implications in Adaptation to a Pathogenic Lifestyle and Perspectives for Drug Design; Abstract; 1 Introduction; 2 Chromosome Replication in Bacteria; 3 Chromosome Replication in Helicobacter pylori; 3.1 Initiation; 3.2 Elongation; 3.3 Termination; 3.4 Segregation. 
505 8 |a 4 Regulation of H. pylori Chromosome Replication5 Plasmid Replication in Bacteria; 6 Plasmid Replication in Helicobacter pylori; 7 Beyond the Replication Flowchart; 8 Concluding Remarks; Acknowledgements; References; 5 The Helicobacter pylori Methylome: Roles in Gene Regulation and Virulence; Abstract; 1 Introduction; 2 The Restriction-Modification (R-M) Systems and Their Diversity in H. pylori; 3 The H. pylori Methylomes; 4 Roles of H. pylori Methyltransferases (Mtases) in Gene Regulation; 4.1 Gene Regulation by E. coli Deoxyadenosine Methyltransferase (Dam) and Its Homologues. 
504 |a Includes bibliographical references. 
590 |a SpringerLink  |b Springer Complete eBooks 
650 0 |a Helicobacter pylori infections  |x Pathogenesis. 
650 0 |a Pathology, Molecular. 
655 7 |a elektronické knihy  |7 fd186907  |2 czenas 
655 9 |a electronic books  |2 eczenas 
700 1 |a Tegtmeyer, Nicole,  |e editor. 
700 1 |a Backert, Steffen,  |e editor. 
776 0 8 |i Print version:  |t Molecular pathogenesis and signal transduction by helicobacter pylori.  |d Cham, Switzerland : Springer, 2017  |z 331950519X  |z 9783319505190  |w (OCoLC)962354656 
830 0 |a Current topics in microbiology and immunology ;  |v 400. 
856 4 0 |u https://proxy.k.utb.cz/login?url=https://link.springer.com/10.1007/978-3-319-50520-6  |y Plný text 
992 |c NTK-SpringerBLS 
999 |c 97153  |d 97153 
993 |x NEPOSILAT  |y EIZ 

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