Human retrotransposons in health and disease

This unique book explores the role of retrotransposons in human health and disease. The ability of retrotransposons to affect the structure of human genes is recognized since the late 80´s. However, the advances of deep-sequencing technologies have shed new light on the extent of retrotransposon-med...

Full description

Saved in:
Bibliographic Details
Other Authors: Cristofari, Gael, (Editor)
Format: eBook
Language: English
Published: Cham : Springer, 2017.
Subjects:
Transposons.
Human genetics.
elektronické knihy
electronic books
ISBN: 9783319483443
9783319483436
Physical Description: 1 online resource

Cover

Table of contents

LEADER 03727cam a2200421Ii 4500
001 97134
003 CZ-ZlUTB
005 20250217131041.0
006 m o d
007 cr cnu|||unuuu
008 170110s2017 sz o 001 0 eng d
999 |c 97134  |d 97134 
020 |a 9783319483443  |q (electronic bk.) 
020 |z 9783319483436 
024 7 |a 10.1007/978-3-319-48344-3  |2 doi 
035 |a (OCoLC)967982017  |z (OCoLC)968646164  |z (OCoLC)974650093  |z (OCoLC)981821054  |z (OCoLC)1005781279  |z (OCoLC)1011847430  |z (OCoLC)1048094231  |z (OCoLC)1058387603  |z (OCoLC)1066654910  |z (OCoLC)1096640748 
040 |a N$T  |b eng  |e rda  |e pn  |c N$T  |d IDEBK  |d GW5XE  |d YDX  |d N$T  |d EBLCP  |d N$T  |d OCLCF  |d UAB  |d COO  |d NJR  |d DKU  |d UPM  |d MERUC  |d IOG  |d MERER  |d ESU  |d OCLCQ  |d JBG  |d IAD  |d ICW  |d ICN  |d OTZ  |d OCLCQ  |d VT2  |d U3W  |d JG0  |d CAUOI  |d CASUM  |d OCLCO  |d OCLCQ  |d KSU  |d AU@  |d OCLCO  |d OCLCQ  |d WYU  |d OCLCQ  |d OCLCA  |d UKMGB  |d OCLCO  |d OCLCA  |d OCLCQ  |d OCLCO  |d UKAHL  |d OCLCQ  |d OCLCA  |d OCLCQ 
245 0 0 |a Human retrotransposons in health and disease /  |c Gael Cristofari, editor. 
264 1 |a Cham :  |b Springer,  |c 2017. 
300 |a 1 online resource 
336 |a text  |b txt  |2 rdacontent 
337 |a počítač  |b c  |2 rdamedia 
338 |a online zdroj  |b cr  |2 rdacarrier 
500 |a Includes index. 
505 0 |a Retrotransposons and the Mammalian Germline -- L1 regulation in Mouse and Human Germ Cells -- Retrotransposon Contribution to Genomic Plasticity -- The Mobilization of Processed Transcripts in Germline and Somatic Tissues -- Neuronal Genome Plasticity: Retrotransposons, Environment and Disease -- Activity of Retrotransposons in Stem Cells and Differentiated Cells -- Environment, Cellular Signaling and L1 activity -- Retrotransposon-derived Regulatory Regions and Transcripts in Stemness -- Roles of Endogenous Retrovirus-encoded Syncytins in Human Placentation -- Alu-Alu Recombinations in Genetic Diseases -- Retrotransposon-driven Transcription and Cancer -- LINE-1 retrotransposons as Neoplastic Biomarkers -- Contribution of Retrotransposable Elements to Aging. 
506 |a Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty 
520 |a This unique book explores the role of retrotransposons in human health and disease. The ability of retrotransposons to affect the structure of human genes is recognized since the late 80´s. However, the advances of deep-sequencing technologies have shed new light on the extent of retrotransposon-mediated genome variations. These progresses have also led to the discovery that retrotransposon activity is not restricted to the germline - resulting in inheritable genetic variations - but can also mobilize in somatic tissues, such as embryonic stem cells, neuronal progenitor cells, or in many cancers. This book covers topics related to the effects of retrotransposon insertions, and their consequences on germline and somatic genome dynamics, but also discuss the role and impact of retrotransposons sequences in a broader context, including a number of novel topics that emerged recently (long non-coding RNA, neuronal disorders, exaptation) with unexpected connections between retrotransposons, stem cell maintenance, placentation, circadian cycles or aging. 
590 |a SpringerLink  |b Springer Complete eBooks 
650 0 |a Transposons. 
650 0 |a Human genetics. 
655 7 |a elektronické knihy  |7 fd186907  |2 czenas 
655 9 |a electronic books  |2 eczenas 
700 1 |a Cristofari, Gael,  |e editor. 
776 0 8 |i Printed edition:  |z 9783319483436 
856 4 0 |u https://proxy.k.utb.cz/login?url=https://link.springer.com/10.1007/978-3-319-48344-3  |y Plný text 
942 |2 udc 
992 |c NTK-SpringerBLS 
993 |x NEPOSILAT  |y EIZ 

Similar Items