Translational medicine and drug discovery

"This book, edited by two leaders known for driving innovation in the field, focuses on the new discipline of translational medicine as it pertains to drug discovery and development within the pharmaceutical and biotechnology industries. Translational medicine seeks to translate biological and...

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Bibliographic Details
Other Authors: Littman, Bruce H., 1944- (Editor), Krishna, Rajesh. (Editor)
Format: eBook
Language: English
Published: Cambridge : Cambridge University Press, 2011.
Subjects:
Drug development.
Molecular pharmacology.
elektronické knihy
electronic books
ISBN: 9781139127035
9781139109840
9780511976087
9781139114202
9781139116374
9780521886451
9781107435940
Physical Description: 1 online zdroj (xx, 361 pages) : illustrations

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Table of contents

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245 0 0 |a Translational medicine and drug discovery /  |c edited by Bruce H. Littman, Rajesh Krishna. 
264 1 |a Cambridge :  |b Cambridge University Press,  |c 2011. 
264 4 |c ©2011 
300 |a 1 online zdroj (xx, 361 pages) :  |b illustrations 
336 |a text  |b txt  |2 rdacontent 
337 |a počítač  |b c  |2 rdamedia 
338 |a online zdroj  |b cr  |2 rdacarrier 
504 |a Includes bibliographical references and index. 
520 |a "This book, edited by two leaders known for driving innovation in the field, focuses on the new discipline of translational medicine as it pertains to drug discovery and development within the pharmaceutical and biotechnology industries. Translational medicine seeks to translate biological and molecular knowledge of disease and how drugs work into innovative strategies that reduce the cost and increase the speed of delivering newmedicines for patients. This book describes these general strategies, biomarker development, imaging tools, translational human models, and examples of their application to real-life drug discovery and development. The latest thinking is presented by researchers from many of the world's leading pharmaceutical companies, including Pfizer, Merck, Eli Lilly, Abbott, and Novartis, as well as from academic institutions and public-private partnerships that support translational research. This book is essential for anyone interested in translational medicine from a variety of backgrounds (university institutes, medical schools, and pharmaceutical companies) in addition to drug development researchers and decision makers."--Publisher's description. 
505 0 0 |g SECTION I:  |t Translational Medicine: History, Principles, and Application in Drug Development --  |g 1.  |t Translational Medicine: Definition, History, and Strategies /  |r Bruce H. Littman --  |g 2.  |t Translational Medicine and Its Impact on Diabetes Drug Development /  |r Roberto A. Calle and Ann E. Taylor --  |g 3.  |t Challenges in Atherosclerosis /  |r John S. Millar --  |g 4.  |t Obesity: New Mechanisms and Translational Paradigms /  |r Gregory Gaich and David E. Moller --  |g 5.  |t Bone Disorders: Translational Medicine Case Studies /  |r S. Aubrey Stoch --  |g 6.  |t Case Studies in Neuroscience: Unique Challenges and Examples Gerard /  |r J. Marek --  |g 7.  |t Translational Medicine in Oncology /  |r Dominic G. Spinella. 
505 8 0 |g SECTION II:  |t Biomarkers and Public-Private Partnerships --  |g 8.  |t Biomarker Validation and Application in Early Drug Development: Idea to Proof of Concept /  |r Pfizer Global Research and Development --  |g 9.  |t Imaging Biomarkers in Drug Development: Case Studies /  |r Johannes T. Tauscher and Adam J. Schwarz --  |g 10.  |t European New Safe and Innovative Medicines Initiatives: History and Progress (through December 2009) /  |r Ole J. Bjerrum and Hans H. Linden --  |g 11.  |t Critical Path Institute and the Predictive Safety Testing Consortium /  |r Elizabeth Gribble Walker --  |g 12.  |t The Biomarkers Consortium: Facilitating the Development and Qualification of Novel Biomarkers Through a Precompetitive Public-Private Partnership /  |r David Wholley and David B. Lee. 
505 8 0 |g SECTION III:  |t Future Directions --  |g 13.  |t Improving the Quality and Productivity of Pharmacometric Modeling and Simulation Activities: the Foundation for Model-Based Drug Development /  |r Thaddeus H. Grasela, Jill Fiedler-Kelly, and Robert Slusser --  |g 14.  |t Embracing Change: a Pharmaceutical Industry Guide to the 21st Century /  |r Mervyn Turner. 
590 |a Knovel Library  |b ACADEMIC - Pharmaceuticals, Cosmetics & Toiletries 
506 |a Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty univerzity 
650 0 |a Drug development. 
650 0 |a Molecular pharmacology. 
655 7 |a elektronické knihy  |7 fd186907  |2 czenas 
655 9 |a electronic books  |2 eczenas 
700 1 |a Littman, Bruce H.,  |d 1944-  |e editor. 
700 1 |a Krishna, Rajesh.  |e editor. 
776 0 8 |i Print version:  |t Translational medicine and drug discovery.  |d New York : Cambridge University Press, 2011  |z 9780521886451  |w (DLC) 2010037116  |w (OCoLC)660509871 
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