Human longevity : omega-3 fatty acids, bioenergetics, molecular biology, and evolution

"Human cells are protected from the ravages of aging by defensive systems including novel mechanisms against membrane oxidation introduced in this book. The book proposes a unified concept in which aging cells faced with declining energy production by mitochondria and the relatively high cost o...

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Bibliographic Details
Main Authors: Valentine, R. C. 1936- (Author), Valentine, David L., (Author)
Format: eBook
Language: English
Published: Boca Raton : Taylor & Francis, [2015]
Subjects:
Aging > Genetic aspects.
Mitochondria.
Oxidative stress.
Omega-3 fatty acids > Health aspects.
elektronické knihy
electronic books
ISBN: 9781466594876
Physical Description: 1 online zdroj : text file, PDF

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Table of contents

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999 |c 75776  |d 75776 
020 |a 9781466594876  |q (e-book :  |q PDF) 
040 |a FlBoTFG  |b eng  |c FlBoTFG  |e rda 
100 1 |a Valentine, R. C.  |q (Raymond Carlyle),  |d 1936-  |e author. 
245 1 0 |a Human longevity :  |b omega-3 fatty acids, bioenergetics, molecular biology, and evolution /  |c Raymond C. Valentine, David L. Valentine. 
264 1 |a Boca Raton :  |b Taylor & Francis,  |c [2015] 
264 4 |c ©2015 
300 |a 1 online zdroj :  |b text file, PDF 
336 |a text  |b txt  |2 rdacontent 
337 |a počítač  |b c  |2 rdamedia 
338 |a online zdroj  |b cr  |2 rdacarrier 
504 |a Includes bibliographical references and index. 
505 0 |a section 1. Introduction to the science of human aging -- section 2. Darwinian selection of membranes enabling longevity -- section 3. Revised mitochondrial membrane hypothesis of aging -- section 4. Many mechanisms have evolved to protect human mitochondrial membranes, enabling longevity. 
506 |a Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty univerzity 
520 |a "Human cells are protected from the ravages of aging by defensive systems including novel mechanisms against membrane oxidation introduced in this book. The book proposes a unified concept in which aging cells faced with declining energy production by mitochondria and the relatively high cost of protecting membranes against oxidation are triggered by energy stress to activate programmed cellular death. It includes case histories illustrating the duality of polyunsaturated membranes in aging and longevity. It also explains the relationship between membrane unsaturation and longevity leading to a unified concept of aging. "--  |c Provided by publisher. 
520 |a "This book is built on the proposition that we age as our mitochondria age. We suggest a revised version of Harman's famous hypothesis featuring mitochondrial oxidative and energy stresses as the root causes of aging. It is well known that cellular death or apoptosis is triggered by energy stress or oxidative stress. There is convincing data showing that as mitochondria age mitochondrial DNA (mtDNA) accumulates mutations decreasing energy output. Protecting highly unsaturated mitochondrial membranes against oxidative stress also consumes an extraordinary amount of energy"--  |c Provided by publisher. 
650 0 |a Aging  |x Genetic aspects. 
650 0 |a Mitochondria. 
650 0 |a Oxidative stress. 
650 0 |a Omega-3 fatty acids  |x Health aspects. 
655 7 |a elektronické knihy  |7 fd186907  |2 czenas 
655 9 |a electronic books  |2 eczenas 
700 1 |a Valentine, David L.,  |e author. 
776 0 8 |i Print version:  |z 9781466594869 (hardback) 
856 4 0 |u https://proxy.k.utb.cz/login?url=https://doi.org/10.1201/b17458  |y Plný text 
942 |2 udc 
992 |a BK  |c EBOOK-TN  |c FOODNB 
993 |x NEPOSILAT  |y EIZ 

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