Systems biology properties of reconstructed networks

• Main Author: Palsson, Bernhard
• Format: eBook
• Language: English
• Published: Cambridge ; New York : Cambridge University Press, 2006.
• Subjects: Computational biology.; Genomics.; Bioinformatics.; Systems biology.; elektronické knihy; electronic books
• ISBN: 9781601197603; 9780511790515
• Physical Description: 1 online zdroj (xii, 322 p.) : ill.

The new discipline of sytems biology examines how genome sequences interact and form networks. This text describes how to model networks, how to determine their properties, and how to relate these to phenotypic functions. The prerequisites for this text are knowledge of linear algebra and biochemist...

Table of Contents:

• 1. Introduction
• 2. Basic concepts in systems biology
• 3. Metabolic networks
• 4. Transcriptional regulatory networks
• 5. Signaling networks
• 6. Basic features of the stoichiometric matrix
• 7. Topological properties
• 8. Fundamental subspaces of S
• 9. The (right) null space of S
• 10. The left null space of S
• 11. The row and column spaces of S
• 12. Dual causality
• 13. Properties of solution spaces
• 14. Sampling solution spaces
• 15. Finding functional states
• 16. Parametric sensitivity
• 17. Epilogue.