Biophysical and Chemical Properties of Collagen : Biomedical Applications

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Bibliographic Details
Main Authors Ramshaw, John A. M. (Author), Glattauer, Veronica (Author)
Format Electronic eBook
LanguageEnglish
Published Bristol [England] (Temple Circus, Temple Way, Bristol BS1 6HG, UK) : IOP Publishing, [2020]
EditionFirst edition.
SeriesBiophysical techniques series (Menlo Park, Calif.)
Subjects
Online AccessFull text
ISBN9780750320962
DOI10.1088/2053-2563/ab2c6b
Physical Description1 online zdroj : ilustrace.

Cover

Table of Contents:
  • 15. Applications of biosynthetic materials
  • 15.1. Vascular devices
  • 15.2. Hernia, ligament and other options
  • 16. Collagen applications in tissue engineering and regenerative medicine
  • 16.1. Fabricated collagen as a supporting structure
  • 16.2. ACM as a supporting structure
  • 17. Coating of biomedical materials with collagen
  • 17.1. Coating of synthetic polymers
  • 17.2. Collagen on metals and inorganic materials
  • 18. Composites of collagen with other materials
  • 18.1. Composites with other biopolymers
  • 18.2. Composites with synthetic polymers
  • 18.3. Composites with inorganic materials
  • 18.4. Composites with bioactive entities
  • part V. Conclusions. 19. Concluding remarks.
  • part I. Introduction. 1. Introduction
  • 1.1. Overview
  • part II. The structure and biochemistry of collagen. 2. The structure of collagen
  • 2.1. Composition
  • 2.2. X-ray diffraction studies
  • 2.3. Different collagen types
  • 2.4. Other proteins with a triple-helix
  • 2.5. Protein sequences
  • 3. Biosynthesis and biodegradation of collagen
  • 3.1. Biosynthetic pathway
  • 3.2. Selected secondary modification enzymes in collagen biosynthesis
  • 3.3. Degradation of collagen in tissues
  • 4. Collagen assemblies
  • 4.1. Ordered collagen structures
  • 4.2. Fibrillogenesis
  • 5. Tissue arrangement
  • 5.1. Formation of new tissue
  • 5.2. Native crosslinking
  • 5.3. Examples of tissue structure
  • 5.4. Mineralisation
  • 5.5. Mechanical properties
  • 6. Collagen stability
  • 6.1. Molecular stability
  • 6.2. Solvent effects on stability
  • 6.3. Peptide models to study stability
  • 6.4. Other uses for peptide models
  • 7. Interactions
  • 7.1. Describing interactions with other molecules
  • 7.2. Interactions with other collagens
  • 7.3. Interactions with proteoglycans
  • 7.4. Interaction with globular proteins
  • 7.5. Interactions with the immune system
  • 7.6. Antibodies to collagens as biochemical reagents
  • part III. The production of collagen-based biomaterials. 8. Production of tissue-derived collagens
  • 8.1. Tissue and fibrous collagen
  • 8.2. Acellular matrix
  • 8.3. Soluble collagens
  • 8.4. Production of collagen in cell culture
  • 8.5. Fractionation of soluble collagens
  • 8.6. Further purification of soluble collagens
  • 9. Production of recombinant collagens
  • 9.1. Recombinant animal collagen production
  • 9.2. Recombinant bacterial collagen production
  • 9.3. Recombinant 'bioengineered' adaptations to collagen structures
  • 9.4. Recombinant chimeric fusion proteins
  • 9.5. De novo designed structures
  • 10. Evaluation of the quality of collagen preparations
  • 10.1. Collagen quantitation
  • 10.2. Solution properties
  • 10.3. Electrophoretic methods
  • 10.4. Optical methods
  • 10.5. Biophysical methods
  • 11. Fabrication of biomedical products
  • 11.1. Gels and hydrogels
  • 11.2. Foams and sponges
  • 11.3. Reconstituted fibres
  • 11.4. Films and membranes
  • 11.5. Beads and particles
  • 11.6. Fibrous capsule materials
  • 11.7. Other technologies
  • 11.8. Sterilisation
  • 12. Chemical modifications
  • 12.1. Chemical crosslinking methods
  • 12.2. Physical crosslinking
  • 12.3. Assessing the effectiveness of crosslinking
  • 12.4. Site-specific chemical modifications
  • part IV. Applications of collagen in medical products. 13. Applications for intact tissue collagen
  • 13.1. Stabilised tissues
  • 13.2. Acellular matrix
  • 14. Applications for purified collagen
  • 14.1. Gels and hydrogels
  • 14.2. Foams and sponges
  • 14.3. Films and membranes
  • 14.4. Beads and particles
  • 14.5. Reconstituted fibres