Imaging Biomarkers : Development and Clinical Integration

This is the first book to cover all aspects of the development of imaging biomarkers and their integration into clinical practice, from the conceptual basis through to the technical aspects that need to be considered in order to ensure that medical imaging can serve as a powerful quantification inst...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Martí-Bonmatí, Luis. (Editor), Alberich-Bayarri, Angel. (Editor)
Format: eBook
Language: English
Published: Cham : Springer International Publishing : Imprint: Springer, 2017.
Subjects:
Medicine.
Radiology.
Biomedical engineering.
elektronické knihy
electronic books
ISBN: 9783319435046
Physical Description: VIII, 316 p. 104 illus., 75 illus. in color. online resource.

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Table of contents

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020 |a 9783319435046 
024 7 |a 10.1007/978-3-319-43504-6  |2 doi 
245 1 0 |a Imaging Biomarkers :  |b Development and Clinical Integration /  |c edited by Luis Martí-Bonmatí, Angel Alberich-Bayarri. 
264 1 |a Cham :  |b Springer International Publishing :  |b Imprint: Springer,  |c 2017. 
300 |a VIII, 316 p. 104 illus., 75 illus. in color.  |b online resource. 
336 |a text  |b txt  |2 rdacontent 
337 |a počítač  |b c  |2 rdamedia 
338 |a online zdroj  |b cr  |2 rdacarrier 
505 0 |a The shift in paradigm to precision medicine in imaging -- International initiatives for the promotion of imaging biomarkers -- Introduction to the stepwise development of imaging biomarkers -- Defining the biological basis and clinical question: proof of concept -- Looking for the inter-relationship: proof of mechanism -- Images acquisition: modality and protocol definition -- Images preparation -- Imaging biomarkers analysis -- Imaging biomarkers measurements -- Detecting measurement biases: the proof of principle -- Validating the imaging biomarker: the proof of efficacy and effectiveness -- The final step: Reporting imaging biomarkers results -- Sources of uncertainty: accuracy and precision of the measurements -- Pearls and pitfalls in Gold standards and biological correlation -- Imaging biobanks, big data and population-based imaging biomarkers -- A proposed Imaging Biomarkers analysis platform architecture for integration in clinics -- Use case I: Imaging biomarkers in neurodegenerative disease -- Use case II: Imaging biomarkers in tumors -- Use case III: Imaging biomarkers in thorax and heart -- Use case IV: Imaging biomarkers in musculoskeletal disorders -- Use case V: Imaging biomarkers in diffuse liver disease. 
506 |a Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty 
520 |a This is the first book to cover all aspects of the development of imaging biomarkers and their integration into clinical practice, from the conceptual basis through to the technical aspects that need to be considered in order to ensure that medical imaging can serve as a powerful quantification instrument capable of providing valuable information on organ and tissue properties. The process of imaging biomarker development is considered step by step, covering proof of concept, proof of mechanism, image acquisition, image preparation, imaging biomarker analysis and measurement, detection of measurement biases (proof of principle), proof of efficacy and effectiveness, and reporting of results. Sources of uncertainty in the accuracy and precision of measurements and pearls and pitfalls in gold standards and biological correlation are discussed. In addition, practical use cases are included on imaging biomarker implementation in brain, oncologic, cardiovascular, musculoskeletal, and abdominal diseases. The authors are a multidisciplinary team of expert radiologists and engineers, and the book will be of value to all with an interest in the quantitative imaging of biomarkers in personalized medicine. 
650 0 |a Medicine. 
650 0 |a Radiology. 
650 0 |a Biomedical engineering. 
655 7 |a elektronické knihy  |7 fd186907  |2 czenas 
655 9 |a electronic books  |2 eczenas 
700 1 |a Martí-Bonmatí, Luis.  |e editor. 
700 1 |a Alberich-Bayarri, Angel.  |e editor. 
710 2 |a SpringerLink (Online service) 
776 0 8 |i Printed edition:  |z 9783319435022 
856 4 0 |u https://proxy.k.utb.cz/login?url=http://dx.doi.org/10.1007/978-3-319-43504-6  |y Plný text 
992 |c NTK-SpringerMED 
999 |c 101742  |d 101742 

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