Patient-Derived Mouse Models of Cancer : Patient-Derived Orthotopic Xenografts (PDOX)

• Corporate Author: SpringerLink (Online service)
• Other Authors: Hoffman, Robert M. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Humana Press, 2017.
• Series: Molecular and Translational Medicine,
• Subjects: Medicine.; Cancer research.; Oncology.; elektronické knihy; electronic books
• ISBN: 9783319574240
• ISSN: 2197-7852
• DOI: 10.1007/978-3-319-57424-0
• Physical Description: XVI, 296 p. 60 illus., 50 illus. in color. online resource.

This text highlights seminal discoveries and also provides comprehensive and state-of the-art approach to mouse models of human patient tumors. These areas include training, basic techniques, as well as general troubleshooting. Subsequent chapters focus on the different mouse models of patient tumor...

Table of Contents:

• In memorium: Jorgen Rygaard (1934-2016) Father of patient derived mouse models of cancer and modern cancer research
• The revival of patient-derived mouse models of cancer: way back to the future
• Patient-derived xenograft models for human cancer, The Freiburg experience
• From Ectopic to Orthotopic Tumor Grafting Sites: Evidence for a Critical Role of the Host Tissue Microenvironment for the Actual Expression of the Malignant Phenotype
• The Effects of the Organ Microenvironment on Metastatic-Cell Gene Signatures
• Techniques for surgical orthotopic implantation of human tumors to immunodeficient mice
• The first patient-derived orthotopic xenograft (PDOX) mouse models of cancer: Cancer of the colon, pancreas, lung, breast, ovary, and mesothelioma
• Patient-derived xenograft models of prostate cancer
• Patient-Derived Mouse Models of Sarcoma
• Cervical cancer patient-derived orthotopic xenograft (PDOX) models
• The use of pediatric patient-derived xenografts for identifying novel agents and combinations
• Development of Orthotopic and Spontaneous Metastatic Human Tumor Xenograft Models for Experimental Therapeutics
• Use of patient-derived orthotopic xenografts (PDOX) to evaluate transformative cancer therapeutics
• Fluorescent protein-expressing transgenic nude mice as hosts for patient tumors
• Fluorescence imaging of tumors in human patient-derived orthotopic xenograft (PDOX) mouse models: The iPDOX model
• The use of patient-derived orthotopic xenograft (PDOX) models to develop curative fluorescence-guided surgery of cancer.-Molecular characteristics of patient-derived tumor xenografts: genomic similarity to patient tumors and relevance for biomarker discovery
• Complementarity of patient-derived orthotopic xenografts (PDOX) models and molecular profiling for optimal therapy
• 3D Cell Culture Models
• Why patient derived mouse models need to be orthotopic
• Foreward: The future of patient-derived models of cancer. .