Moyamoya Disease Explored Through RNF213 : Genetics, Molecular Pathology, and Clinical Sciences

This book presents the latest findings on biological, epidemiological, and clinical investigations of RNF213, which is thought to be involved in many biological processes and plays a key role in cerebro- and cardiovascular disease . By discussing the epidemiology and genetic epidemiology of the dise...

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Bibliographic Details
Corporate Author SpringerLink (Online service)
Other Authors Koizumi, Akio (Editor), Nagata, Kazuhiro (Editor), Houkin, Kiyohiro (Editor), Tominaga, Teiji (Editor), Miyamoto, Susumu (Editor), Kure, Shigeo (Editor), Tournier-Lasserve, Elizabeth (Editor)
Format Electronic eBook
LanguageEnglish
Published Singapore : Springer Singapore : Imprint: Springer, 2017.
SeriesCurrent Topics in Environmental Health and Preventive Medicine,
Subjects
Medicine.
Public health.
Neurology.
Neurosurgery.
elektronické knihy
electronic books
Online AccessFull text
ISBN9789811027116
ISSN2364-8333
DOI10.1007/978-981-10-2711-6
Physical DescriptionVIII, 185 p. 36 illus., 22 illus. in color. online resource.

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Table of Contents:
  • Part I: Prologue
  • 1. A prologue to moyamoya disease and RNF213
  • 2. Concept of moyamoya Disease
  • Part II: Genetic Epidemiology
  • 3. Molecular Epidemiology in East Asian Countries and in the World
  • Part III: Biochemistry, Function and Molecular Pathology
  • 4. Molecular Biology of Mysterin/RNF213
  • 5. Physiological Role of Mysterin/RNF213 in Zebrafish
  • 6. Pathological Investigation on RNF213: Animal Models Knockout and Transgenic Mice in Diabetes and Signal Transduction
  • 7. Pathological Investigation on RNF213: Animal Models of Rnf213-knockout and Knock-in Mice
  • 8. RNF213 and Circulating Factors in Patients with Moyamoya Disease
  • 9. Genetics of Moyamoya beyond RNF213. Monogenic Moyamoya Syndromes
  • Part IV: Clinical Management 10. Natural History and Long-term Clinical Outcome after Conservative and Surgical Management
  • 11. Significance of RNF213 in Clinical Management in Japan
  • 12. Significance of RNF213 in Clinical Management in China
  • 13. The Different Forms of Moyamoya Disease and Their Clinical Management
  • 14. Vascular Diseases Attributable to RNF213 Other than Moyamoya Disease
  • Part V: Epilogue
  • Future Clinical Perspectives on RNF213 in Moyamoya Disease.

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