The Blood Brain Barrier and Inflammation

Within the central nervous system (CNS) the constantly changing blood stream is separated from the CNS parenchyma by the blood brain barrier (BBB) restricting passage to selected immune cells. Under pathological conditions, however, viruses, bacteria, parasites and autoaggressive immune cells can pe...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Lyck, Ruth. (Editor), Enzmann, Gaby. (Editor)
Format: eBook
Language: English
Published: Cham : Springer International Publishing : Imprint: Springer, 2017.
Series: Progress in Inflammation Research
Subjects:
Medicine.
Immunology.
Neurosciences.
Infectious diseases.
Cytokines.
Growth factors.
Cell membranes.
elektronické knihy
electronic books
ISBN: 9783319455143
Physical Description: VI, 286 p. 32 illus., 24 illus. in color. online resource.

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LEADER 03755nam a22004455i 4500
001 101487
003 CZ-ZlUTB
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006 m o d
007 cr nn 008mamaa
008 170329s2017 gw | s |||| 0|eng d
020 |a 9783319455143 
024 7 |a 10.1007/978-3-319-45514-3  |2 doi 
245 1 4 |a The Blood Brain Barrier and Inflammation /  |c edited by Ruth Lyck, Gaby Enzmann. 
264 1 |a Cham :  |b Springer International Publishing :  |b Imprint: Springer,  |c 2017. 
300 |a VI, 286 p. 32 illus., 24 illus. in color.  |b online resource. 
336 |a text  |b txt  |2 rdacontent 
337 |a počítač  |b c  |2 rdamedia 
338 |a online zdroj  |b cr  |2 rdacarrier 
490 1 |a Progress in Inflammation Research 
505 0 |a General Introduction to Barrier Mechanisms in the Central Nervous System -- Topological Aspects of the Blood-brain and Blood cerebrospinal Fluid Barriers and their Relevance in Inflammation Research -- The Contribution of the Extracellular Matrix to the BBB in Steady State and Inflammatory Conditions -- Pathophysiology of the Bloodbrain Barrier in Neuroinflammatory Diseases -- Leakage at Blood-neural Barriers -- Blood-Brain Barrier Transporters and Neuroinflammation: Partners in Neuroprotection and in Pathology -- MicroRNAs in Brain Endothelium and Inflammation -- Blood-Brain Barrier Dysfunction during Central Nervous System Autoimmune Diseases -- Pathways Across the Blood Brain Barrier -- Neuroinflammation in Bacterial Meningitis -- Blood Vessels in the Brain: a Signaling Hub in Brain Tumor Inflammation. 
506 |a Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty 
520 |a Within the central nervous system (CNS) the constantly changing blood stream is separated from the CNS parenchyma by the blood brain barrier (BBB) restricting passage to selected immune cells. Under pathological conditions, however, viruses, bacteria, parasites and autoaggressive immune cells can penetrate the barrier and contribute to CNS inflammation. The BBB actively contributes to neuroinflammation by presentation of chemokines, expression of cell adhesion molecules and alteration of barrier properties. As such, understanding the role of the BBB under healthy and pathological conditions is essential for the development of new drugs to efficiently combat inflammatory diseases of the CNS. This book presents a comprehensive collection of reviews that focus on the role of the BBB. Experts in the field share their insight on structural, topological and functional properties of the BBB. They elaborate on pathophysiological changes of the inflamed BBB such as permeability, transporter proteins and alterations in microRNAs and cytokine profile. Additional chapters on multiple sclerosis and bacterial meningitis provide in depth information on significant neuroinflammatory diseases. The selection is complemented by a review on the current understanding of the BBB as signaling hub in tumor pathogenesis in the brain. 
650 0 |a Medicine. 
650 0 |a Immunology. 
650 0 |a Neurosciences. 
650 0 |a Infectious diseases. 
650 0 |a Cytokines. 
650 0 |a Growth factors. 
650 0 |a Cell membranes. 
655 7 |a elektronické knihy  |7 fd186907  |2 czenas 
655 9 |a electronic books  |2 eczenas 
700 1 |a Lyck, Ruth.  |e editor. 
700 1 |a Enzmann, Gaby.  |e editor. 
710 2 |a SpringerLink (Online service) 
776 0 8 |i Printed edition:  |z 9783319455129 
830 0 |a Progress in Inflammation Research 
856 4 0 |u https://proxy.k.utb.cz/login?url=http://dx.doi.org/10.1007/978-3-319-45514-3  |y Plný text 
992 |c NTK-SpringerMED 
999 |c 101487  |d 101487 

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