Patient-Derived Xenograft Models of Human Cancer

This book provides a comprehensive, state-of-the-art review of PDX cancer models. In separately produced chapters, the history and evolution of PDX models is reviewed, methods of PDX model development are compared in detail, characteristics of available established models are presented, current appl...

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Bibliographic Details
Corporate Author SpringerLink (Online service)
Other Authors Wang, Yuzhuo (Editor), Lin, Dong (Editor), Gout, Peter W. (Editor)
Format Electronic eBook
LanguageEnglish
Published Cham : Springer International Publishing : Imprint: Humana Press, 2017.
SeriesMolecular and Translational Medicine,
Subjects
Medicine.
Oncology.
elektronické knihy
electronic books
Online AccessFull text
ISBN9783319558257
ISSN2197-7852
DOI10.1007/978-3-319-55825-7
Physical DescriptionXI, 204 p. 27 illus., 26 illus. in color. online resource.

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Table of Contents:
  • Introduction
  • History and Evolution of PDX Cancer Models
  • Establishment and Characterization of PDX Models
  • Methods of Generating PDX Models
  • Fidelity and Stability of PDX Models
  • Applications of PDX Models
  • Studies of Cancer Heterogeneity
  • PDX and Cancer Stem Cells
  • Modeling Cancer Metastasis
  • Modeling Drug Resistance
  • PDX and Biomarker Development
  • PDX and Preclinical Drug Screening
  • Co-clinical Trials and Personalized Cancer Therapy/Precision Medicine
  • Epilogue
  • Future Perspective.

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