Immunotherapy for Gastrointestinal Cancer

This book is about the manipulation of the immune system as a therapeutic approach to gastrointestinal cancer and its clinical applications, exploring therapeutic approaches which might be taken under the broad banner of immunotherapy. Starting by introducing concepts of modern immunology, the clini...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Kerr, David. (Editor), Johnson, Rebecca. (Editor)
Format: eBook
Language: English
Published: Cham : Springer International Publishing : Imprint: Springer, 2017.
Subjects:
Medicine.
Immunology.
Gastroenterology.
Oncology.
elektronické knihy
electronic books
ISBN: 9783319430638
Physical Description: VIII, 252 p. 23 illus. in color. online resource.

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Table of contents

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001 101271
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006 m o d
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008 170102s2017 gw | s |||| 0|eng d
020 |a 9783319430638 
024 7 |a 10.1007/978-3-319-43063-8  |2 doi 
245 1 0 |a Immunotherapy for Gastrointestinal Cancer /  |c edited by David Kerr, Rebecca Johnson. 
264 1 |a Cham :  |b Springer International Publishing :  |b Imprint: Springer,  |c 2017. 
300 |a VIII, 252 p. 23 illus. in color.  |b online resource. 
336 |a text  |b txt  |2 rdacontent 
337 |a počítač  |b c  |2 rdamedia 
338 |a online zdroj  |b cr  |2 rdacarrier 
505 0 |a Introduction to modern immunology -- Cell based therapy - modified cancer cells -- Vaccines for GI cancer -- Antibody delivery of radioactive 'warheads' and cytotoxins -- Antibodies which inhibit specific cell pathways -- PD1 and PD1l immune checkpoint inhibitors -- The Role of the JAK/STAT Signaling Pathway in Immunoregulation of Gastrointestinal Cancers -- Hyper mutated colorectal cancer and neoantigen load -- Antibodies which inhibit specific cell pathways, colorectal cancer. 
506 |a Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty 
520 |a This book is about the manipulation of the immune system as a therapeutic approach to gastrointestinal cancer and its clinical applications, exploring therapeutic approaches which might be taken under the broad banner of immunotherapy. Starting by introducing concepts of modern immunology, the clinical applications of immunotherapy are then discussed. The reader will learn about the three broad classes of immune therapeutic agents: cell-based treatment; antibody therapy; cytokine application and the key effector cells and mechanisms which might cause tumour rejection. The reverse side of this equation, the genetic and molecular mechanisms which the tumour can use to escape immune control and regulation, is also discussed. Through reviewing the most up-to-date evidence, this volume provides an overview of the important scientific lessons learned from past failure of immunotherapeutics in the clinic and highlights more positive recent data, coupled to practical guidelines for clinical usage. Written by a team of worldwide experts, this is an indispensable guide for medical oncologists, surgical oncologists, radiation therapists, pharmacists, oncology nurse specialists. . 
650 0 |a Medicine. 
650 0 |a Immunology. 
650 0 |a Gastroenterology. 
650 0 |a Oncology. 
655 7 |a elektronické knihy  |7 fd186907  |2 czenas 
655 9 |a electronic books  |2 eczenas 
700 1 |a Kerr, David.  |e editor. 
700 1 |a Johnson, Rebecca.  |e editor. 
710 2 |a SpringerLink (Online service) 
776 0 8 |i Printed edition:  |z 9783319430614 
856 4 0 |u https://proxy.k.utb.cz/login?url=http://dx.doi.org/10.1007/978-3-319-43063-8  |y Plný text 
992 |c NTK-SpringerMED 
999 |c 101271  |d 101271 

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