Cardiovascular Safety in Drug Development and Therapeutic Use : New Methodologies and Evolving Regulatory Landscapes

With the advent of multiple new therapeutic agents for a variety of important diseases has come an increasing realization that many of these drugs can have adverse effects on the heart and vascular system. As this book so elegantly details the mechanisms by which harm occurs are highly complex, many...

Full description

Saved in:
Bibliographic Details
Main Authors: Turner, J. Rick. (Author), Karnad, Dilip R. (Author), Kothari, Snehal. (Author)
Corporate Author: SpringerLink (Online service)
Format: eBook
Language: English
Published: Cham : Springer International Publishing : Imprint: Adis, 2017.
Subjects:
Medicine.
Cardiology.
Pharmacy.
elektronické knihy
electronic books
ISBN: 9783319403472
Physical Description: XXVI, 342 p. 2 illus. in color. online resource.

Cover

Table of contents

LEADER 03752nam a22003975i 4500
001 101194
003 CZ-ZlUTB
005 20240914113254.0
006 m o d
007 cr nn 008mamaa
008 160728s2017 gw | s |||| 0|eng d
020 |a 9783319403472 
024 7 |a 10.1007/978-3-319-40347-2  |2 doi 
100 1 |a Turner, J. Rick.  |e author. 
245 1 0 |a Cardiovascular Safety in Drug Development and Therapeutic Use :  |b New Methodologies and Evolving Regulatory Landscapes /  |c by J. Rick Turner, Dilip R. Karnad, Snehal Kothari. 
264 1 |a Cham :  |b Springer International Publishing :  |b Imprint: Adis,  |c 2017. 
300 |a XXVI, 342 p. 2 illus. in color.  |b online resource. 
336 |a text  |b txt  |2 rdacontent 
337 |a počítač  |b c  |2 rdamedia 
338 |a online zdroj  |b cr  |2 rdacarrier 
505 0 |a The Central Importance of Cardiovascular Safety in Contemporary New Drug Development -- The Biological Basis of Drug Responses -- Cardiovascular Structure, Function, Pathophysiology, & Disease -- The Current Regulatory Landscape -- The "Comprehensive In Vitro Proarrhythmia Assay" Initiative -- The "Early ECG Assessment" Initiative -- The "Submission of Extended Digital ECG Data" Initiative -- Meta-analysis and Meta-methodology -- Current Regulatory Landscapes and their Potential Evolution -- Off-target Blood Pressure Responses to Non-cardiovascular Drugs -- Oncology Drug Development and Therapeutics: Cardiotoxicity Considerations -- Postmarketing Surveillance -- Regulatory Perspectives on General Drug Safety -- Future Directions in Cardiovascular Safety -- References. 
506 |a Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty 
520 |a With the advent of multiple new therapeutic agents for a variety of important diseases has come an increasing realization that many of these drugs can have adverse effects on the heart and vascular system. As this book so elegantly details the mechanisms by which harm occurs are highly complex, many times predictable, but always clinically relevant. Notable experts in the field of cardiovascular medicine, such as Drs. Turner, Karnad, and Kothari, have turned their attention to this thorny problem, and begun to dissect the diverse mechanisms by which cardiac harm can occur with a variety of non-cardiac drugs. This is no easy task, given the complexity of the diseases we treat, and the wide spectrum of new therapies we seek to apply. However, it is an issue with which all health care providers must become familiar in order to prescribe appropriate therapy while safeguarding patients against avoidable and life-threatening cardiac adverse effects. This compendium represents the state-of-the-art in the evolving field of cardiac safety and is vital reading for those interested in developing new chemical entities, as well as those who prescribe them and monitor patients for their hazard. As such, I recommend this book as essential reading for students, scientists, and health care providers at all levels of training. Peter R. Kowey, MD, FACC, FAHA, FHRS Lankenau Institute for Medical Research & Thomas Jefferson University. 
650 0 |a Medicine. 
650 0 |a Cardiology. 
650 0 |a Pharmacy. 
655 7 |a elektronické knihy  |7 fd186907  |2 czenas 
655 9 |a electronic books  |2 eczenas 
700 1 |a Karnad, Dilip R.  |e author. 
700 1 |a Kothari, Snehal.  |e author. 
710 2 |a SpringerLink (Online service) 
776 0 8 |i Printed edition:  |z 9783319403458 
856 4 0 |u https://proxy.k.utb.cz/login?url=http://dx.doi.org/10.1007/978-3-319-40347-2  |y Plný text 
992 |c NTK-SpringerMED 
999 |c 101194  |d 101194 
993 |x NEPOSILAT  |y EIZ 

Similar Items