Paroxysmal Nocturnal Hemoglobinuria : From Bench to Bedside

This volume reviews the fundamental understanding of this potentially life-threatening disease and the advances in treatment that have been achieved with the use of the monoclonal antibody eculizumab. Although the PIGA gene has been known for many years, the mechanism of clonal dominance in paroxysm...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Kanakura, Yuzuru. (Editor), Kinoshita, Taroh. (Editor), Nishimura, Jun-ichi. (Editor)
Format: eBook
Language: English
Published: Tokyo : Springer Japan : Imprint: Springer, 2017.
Subjects:
Medicine.
Immunology.
Hematology.
elektronické knihy
electronic books
ISBN: 9784431560036
Physical Description: VIII, 358 p. 71 illus., 46 illus. in color. online resource.

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Table of contents

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020 |a 9784431560036 
024 7 |a 10.1007/978-4-431-56003-6  |2 doi 
245 1 0 |a Paroxysmal Nocturnal Hemoglobinuria :  |b From Bench to Bedside /  |c edited by Yuzuru Kanakura, Taroh Kinoshita, Jun-ichi Nishimura. 
264 1 |a Tokyo :  |b Springer Japan :  |b Imprint: Springer,  |c 2017. 
300 |a VIII, 358 p. 71 illus., 46 illus. in color.  |b online resource. 
336 |a text  |b txt  |2 rdacontent 
337 |a počítač  |b c  |2 rdamedia 
338 |a online zdroj  |b cr  |2 rdacarrier 
505 0 |a 1 A History of Research of PNH: Defining a Disease -- Part I Basic Sciences in PNH -- 2 Synthesis, genetics and congenital diseases of GPI-anchored proteins -- 3 Animal models of paroxysmal nocturnal hemoglobinuria -- 4 Complement and PNH -- Part II Clinical Sciences in PNH -- 5 Epidemiology in PNH: The PNH Global Registry -- 6 Epidemiology in PNH; Clinical Epidemiological Studies in Korea -- 7 Hemolysis in PNH; Depletion of nitric oxide -- 8 Bone Marrow Failure in PNH -- 9 Thrombophilia in PNH -- 10 Diagnosis and Classification of PNH -- 11 Clinical significance of a small population of glycosyl phosphatidylinositol-anchored membrane proteins (GPI-APs)-deficient cells in the management of bone marrow failure -- 12 CLONAL ORIGIN AND CLONAL SELECTION IN PNH -- 13 Pathogenesis of clonal dominance in PNH: Selection mechanisms in PNH -- 14 Pathogenesis of Clonal Dominance in PNH; Growth Advantage in PNH -- 15 Clinical Management in PNH -- 16 CLINICAL EFFECTS OF ECULIZUMAB IN PNH -- 17 Clinical Effects of Eculizumab in PNH; Extravascular Hemolysis after Eculizumab Treatment -- 18 Clinical Effects of Eculizumab in PNH; Poor-Responders to Eculizumab -- 19 Hematopoietic Stem Cell Transplantation in PNH -- 20 Future strategies of complement inhibition in paroxysmal nocturnal hemoglobinuria -- 21 Pregnancy in paroxysmal nocturnal hemoglobinuria. 
506 |a Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty 
520 |a This volume reviews the fundamental understanding of this potentially life-threatening disease and the advances in treatment that have been achieved with the use of the monoclonal antibody eculizumab. Although the PIGA gene has been known for many years, the mechanism of clonal dominance in paroxysmal nocturnal hemoglobinuria is still largely unknown. This book, Paroxysmal Nocturnal Hemoglobinuria, discusses the direction of continuing research in this area, as well as the potential for the development of management guidelines. It serves as a valuable source of information for both basic scientists and physicians, especially immunologists targeting GPI-anchored proteins and complements, and hematologists specializing in bone marrow failure. 
650 0 |a Medicine. 
650 0 |a Immunology. 
650 0 |a Hematology. 
655 7 |a elektronické knihy  |7 fd186907  |2 czenas 
655 9 |a electronic books  |2 eczenas 
700 1 |a Kanakura, Yuzuru.  |e editor. 
700 1 |a Kinoshita, Taroh.  |e editor. 
700 1 |a Nishimura, Jun-ichi.  |e editor. 
710 2 |a SpringerLink (Online service) 
776 0 8 |i Printed edition:  |z 9784431560012 
856 4 0 |u https://proxy.k.utb.cz/login?url=http://dx.doi.org/10.1007/978-4-431-56003-6  |y Plný text 
992 |c NTK-SpringerMED 
999 |c 101182  |d 101182 

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