Next-Generation Therapies and Technologies for Immune-Mediated Inflammatory Diseases

As our understanding of immune mediated chronic inflammatory diseases (IMIDs) grows, it becomes more and more clear that these conditions result from the convergence of a multitude of pathogenic mechanisms whose relative individual contribution is different in different patient subsets. Promising ne...

Full description

Saved in:
Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Mina-Osorio, Paola. (Editor)
Format: eBook
Language: English
Published: Cham : Springer International Publishing : Imprint: Springer, 2017.
Series: Progress in Inflammation Research
Subjects:
Medicine.
Pharmacy.
Gene therapy.
Immunology.
Pharmaceutical technology.
elektronické knihy
electronic books
ISBN: 9783319422527
Physical Description: XI, 202 p. 8 illus., 6 illus. in color. online resource.

Cover

Table of contents

LEADER 04289nam a22004215i 4500
001 101177
003 CZ-ZlUTB
005 20240914113249.0
006 m o d
007 cr nn 008mamaa
008 170124s2017 gw | s |||| 0|eng d
020 |a 9783319422527 
024 7 |a 10.1007/978-3-319-42252-7  |2 doi 
245 1 0 |a Next-Generation Therapies and Technologies for Immune-Mediated Inflammatory Diseases /  |c edited by Paola Mina-Osorio. 
264 1 |a Cham :  |b Springer International Publishing :  |b Imprint: Springer,  |c 2017. 
300 |a XI, 202 p. 8 illus., 6 illus. in color.  |b online resource. 
336 |a text  |b txt  |2 rdacontent 
337 |a počítač  |b c  |2 rdamedia 
338 |a online zdroj  |b cr  |2 rdacarrier 
490 1 |a Progress in Inflammation Research 
505 0 |a Preface -- Targeted drug delivery -- I. Bispecific antibodies -- II. Targeting neovessels with NGR peptides -- Genomic-based drugs -- III. Micro-RNA/aptamers -- Nanomedicine -- IV. Exosomes -- V. Microparticles -- Cross-functional targets -- VI. Metabolic targets in inflammation -- VII. Targeting gut microbiome-immune system interactions -- VIII. Targeting the nervous system as an add on therapy for autoinflammatory conditions -- Biomarkers -- IX. Biomarkers in drug discovery -- Other therapies -- X. Stem cell therapy in the treatment of rheumatic disease and application in the treatment of systemic lupus erythematosus. 
506 |a Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty 
520 |a As our understanding of immune mediated chronic inflammatory diseases (IMIDs) grows, it becomes more and more clear that these conditions result from the convergence of a multitude of pathogenic mechanisms whose relative individual contribution is different in different patient subsets. Promising new technologies have been conceived that address the hypotheses that targeting multiple pathways simultaneously, selectively delivering therapeutics to areas of inflammation and/or resetting the immune system, could take efficacy to new levels. However, we have long waited for the arrival of some of these technologies to the bedside, or even far enough in the drug development process in spite of the initial enthusiasm. Some of the examples covered in this book include bispecific antibodies and genomic medicines, microparticles and targeted delivery of drugs to inflamed vasculature. Most published reviews and book chapters on novel therapies for inflammatory diseases describe positive attributes of molecules or technologies under investigation and the rationale for developing them into therapeutics. The originality and potential value of this book is not in the description of these targets or technologies from the point of view of their structure or mechanism of action exclusively, but rather, in making an effort to critically address the question of what is needed to move these technologies into the clinic. Has the technology not made it past the preclinical stage and why? Has it already been tested in humans and failed? What are the potential reasons behind those failures? What do experts in each field believe can be done better to increase the probabilities of success? In addition, the authors address the competitive landscape and summarize clinical studies that have failed in the respective area. They talk about the patient populations that would be required for the successful conduction of a clinical trial to test certain molecules, and they proactively share their views regarding both the potential and the drawbacks of targets or methodologies. 
650 0 |a Medicine. 
650 0 |a Pharmacy. 
650 0 |a Gene therapy. 
650 0 |a Immunology. 
650 0 |a Pharmaceutical technology. 
655 7 |a elektronické knihy  |7 fd186907  |2 czenas 
655 9 |a electronic books  |2 eczenas 
700 1 |a Mina-Osorio, Paola.  |e editor. 
710 2 |a SpringerLink (Online service) 
776 0 8 |i Printed edition:  |z 9783319422510 
830 0 |a Progress in Inflammation Research 
856 4 0 |u https://proxy.k.utb.cz/login?url=http://dx.doi.org/10.1007/978-3-319-42252-7  |y Plný text 
992 |c NTK-SpringerMED 
999 |c 101177  |d 101177 
993 |x NEPOSILAT  |y EIZ 

Similar Items