Incorporation of Heterocycles into Combinatorial Chemistry

The author has summarized a decade of teaching combinatorial chemistry into this timely brief. The solid phase synthesis of unnatural heterocyclic alpha-amino acids is illustrated by practical examples starting from the ABCs of peptide synthesis explored in chapter one. Chapter two is concerned with...

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Bibliographic Details
Main Author: Babaev, Eugene V. (Author)
Corporate Author: SpringerLink (Online service)
Format: eBook
Language: English
Published: Cham : Springer International Publishing : Imprint: Springer, 2017.
Series: SpringerBriefs in Molecular Science,
Subjects:
Chemistry.
Pharmaceutical technology.
Organic chemistry.
Science education.
elektronické knihy
electronic books
ISBN: 9783319500157
Physical Description: 1 online resource (XI, 117 p. 106 illus.)

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020 |a 9783319500157 
024 7 |a 10.1007/978-3-319-50015-7  |2 doi 
100 1 |a Babaev, Eugene V.  |e author. 
245 1 0 |a Incorporation of Heterocycles into Combinatorial Chemistry /  |c by Eugene V. Babaev. 
264 1 |a Cham :  |b Springer International Publishing :  |b Imprint: Springer,  |c 2017. 
300 |a 1 online resource (XI, 117 p. 106 illus.) 
336 |a text  |b txt  |2 rdacontent 
337 |a počítač  |b c  |2 rdamedia 
338 |a online zdroj  |b cr  |2 rdacarrier 
490 1 |a SpringerBriefs in Molecular Science,  |x 2191-5407 
505 0 |a Introduction -- Peptide Synthesis of Libraries of Non-Natural Amino Acids -- The choice of tools for implementing multi-stage transformations. SPOS for Beginners -- Secrets of Parallel Liquid-Phase Synthesis -- Most Combinatorial LPOS Reactions: Reductive Amination with a Scavenger -- A Parallel Ugi Reaction -- Combinatorial Heterocyclic Chemistry in Higher School. 
506 |a Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty 
520 |a The author has summarized a decade of teaching combinatorial chemistry into this timely brief. The solid phase synthesis of unnatural heterocyclic alpha-amino acids is illustrated by practical examples starting from the ABCs of peptide synthesis explored in chapter one. Chapter two is concerned with the solid phase synthesis which is shown on various techniques - BillBoard, tea-bag, and Lantern devices, and demonstrated on heterocyclic examples and protocols. In the third chapter the tools for accelerating chemical synthesis - solid phase and liquid phase - are reviewed. Here the techniques of parallel refluxing (including microwave and flow technique) and parallel separation (filtration, centrifugation, evaporation, and chromatography) are described. In the chapters 4 and 5 the author goes on to describe how the liquid phase synthesis of heterocycles (reductive amination and Ugi reaction of heterocycles) is illustrated with the use of semi-automated protocols. Finally, the design of combinatorial libraries of heterocycles is reviewed including the original author's findings. 
650 0 |a Chemistry. 
650 0 |a Pharmaceutical technology. 
650 0 |a Organic chemistry. 
650 0 |a Science education. 
655 7 |a elektronické knihy  |7 fd186907  |2 czenas 
655 9 |a electronic books  |2 eczenas 
710 2 |a SpringerLink (Online service) 
776 0 8 |i Printed edition:  |z 9783319500133 
830 0 |a SpringerBriefs in Molecular Science,  |x 2191-5407 
856 4 0 |u https://proxy.k.utb.cz/login?url=http://dx.doi.org/10.1007/978-3-319-50015-7  |y Plný text 
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