Point-of-care solution for osteoporosis management : design, fabrication, and validation of new technology.

This book addresses the important clinical problem of accurately diagnosing osteoporosis, and analyzes how Bone Turnover Markers (BTMs) can improve osteoporosis detection. In her research, the author integrated microfluidic technology with electrochemical sensing to embody a reaction/detection chamb...

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Bibliographic Details
Main Author: Khashayar, Patricia.
Format: eBook
Language: English
Published: Cham : Springer, 2017.
Subjects:
Osteoporosis > Prevention.
elektronické knihy
electronic books
ISBN: 9783319550534
9783319550527
Physical Description: 1 online resource

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Table of contents

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100 1 |a Khashayar, Patricia. 
245 1 0 |a Point-of-care solution for osteoporosis management :  |b design, fabrication, and validation of new technology. 
260 |a Cham :  |b Springer,  |c 2017. 
300 |a 1 online resource 
336 |a text  |b txt  |2 rdacontent 
337 |a počítač  |b c  |2 rdamedia 
338 |a online zdroj  |b cr  |2 rdacarrier 
504 |a Includes bibliographical references. 
505 0 |a Preface; Acknowledgments; Contents; Acronyms; Glossary; 1 Introduction; 1.1 Importance of Point-of-Care Testing in Osteoporosis Management; 1.1.1 The Concept of Bone Remodeling; 1.1.2 What Is Osteoporosis?; 1.1.2.1 Epidemiology of Osteoporosis; 1.1.2.2 Osteoporosis Risk Factors; 1.1.2.3 Complications of Osteoporosis; 1.1.3 Osteoporosis Detection Techniques; 1.1.3.1 Dual-Energy X-Ray Absorptiometry; 1.1.3.2 Other Imaging Modalities; 1.1.3.3 Fracture Risk Assessment Tool; 1.1.4 Early Diagnosis in Osteoporosis Detection; 1.2 The Aim of Current Book; 1.2.1 PoC and Osteoporosis. 
505 8 |a 1.3 Organization of the BookReferences; 2 Literature Overview; 2.1 Bone Turnover Markers and Osteoporosis; 2.1.1 Introduction; 2.1.2 What Are Biomarkers; 2.1.3 Bone Turnover Markers (BTMs); 2.1.3.1 Advantages of Using BTMs; 2.1.3.2 Disadvantage of Using BTMs; 2.1.4 BTM Classification; 2.1.4.1 Data Sources; 2.1.4.2 Inclusion Criteria; 2.1.4.3 Exclusion Criteria; 2.1.4.4 Main BTMs; 2.1.5 Biomarker Setbacks (with Focus on BTMs); 2.1.5.1 Marker Limitations; 2.1.5.2 Measurement Technique Limitations; 2.1.6 Conclusion; 2.2 Bone Biosensors: Knowing the Present and Predicting the Future. 
505 8 |a 2.2.1 Current Approaches to Assess Bone Remodeling2.2.2 Conclusion and Future Directions; 2.3 Protein Immobilization Strategies for Biosensing Purposes; 2.3.1 Physisorption; 2.3.2 Electrostatic Interaction; 2.3.3 Covalent Binding; 2.3.3.1 Amine Chemistry; 2.3.3.2 Carboxyl Chemistry; 2.3.3.3 Thiol Chemistry; 2.3.3.4 Tyrosine and Tryptophan; 2.3.4 Bioaffinity Immobilization; 2.3.4.1 Avidin-Biotin; 2.3.4.2 Protein A/G-Antibody; 2.3.4.3 Site-Specific Covalent Immobilization; 2.3.4.4 Affinity Tags; 2.3.5 Conclusion; References; 3 Scientific Background; 3.1 Overview on Immunosensors. 
505 8 |a 3.1.1 Introduction3.1.2 What Is a Biosensor; 3.1.3 Main Types of Immunoassays; 3.1.3.1 Heterogeneous Immunoassays; 3.1.3.2 Homogenous Immunoassays; 3.1.4 Immunosensor Components; 3.1.4.1 Carbon Nanotubes; 3.1.4.2 Nanoparticles; 3.1.5 Detection Techniques; 3.2 Electrochemistry: Principles; 3.2.1 Cyclic Voltammetry; 3.2.2 Differential Pulse Voltammetry; 3.2.3 Chronoamperometry; 3.2.4 Chronocoulometry; 3.2.5 Electrochemical Impedance Spectroscopy; 3.3 Basic Concepts in Microfluidic Devices; 3.3.1 Materials for the Microfluidic Devices; 3.3.2 Surface Modification. 
505 8 |a 3.3.3 Introducing Sample/Reagent and Moving Fluid Within the Microfluidic3.3.3.1 Pressure Driven Flow; 3.3.3.2 Electrokinetic Flow; 3.3.3.3 Capillary Flow; 3.3.4 Detection; 3.3.5 Design; References; 4 Conjugated AuNP-Antibody Nanoprobe Fabricationand Validation; 4.1 Introduction; 4.2 Synthesis of a Conjugated AuNP-Antibody Nanoprobe; 4.2.1 Synthesis of AuNPs; 4.2.2 AuNP-Antibody Conjugation; 4.3 Characterization of Conjugated AuNP-Antibody Nanoprobe; 4.3.1 Characterization of AuNPs; 4.3.2 Characterization of AuNP/Ab Nanocomplex; 4.4 Optimization of AuNP/Ab Nanoconjugate Preparation. 
506 |a Plný text je dostupný pouze z IP adres počítačů Univerzity Tomáše Bati ve Zlíně nebo vzdáleným přístupem pro zaměstnance a studenty 
520 |a This book addresses the important clinical problem of accurately diagnosing osteoporosis, and analyzes how Bone Turnover Markers (BTMs) can improve osteoporosis detection. In her research, the author integrated microfluidic technology with electrochemical sensing to embody a reaction/detection chamber to measure serum levels of different biomarkers, creating a microfluidic proteomic platform that can easily be translated into a biomarker diagnostic. The Osteokit System, a result of the integration of electrochemical system and microfluidic chips, is a unique design that offers the potential for greater sensitivity. The implementation, feasibility, and specificity of the Osteokit platform is demonstrated in this book, which is appropriate for researchers working on bone biology and mechanics, as well as clinicians. 
590 |a SpringerLink  |b Springer Complete eBooks 
650 0 |a Osteoporosis  |x Prevention. 
655 7 |a elektronické knihy  |7 fd186907  |2 czenas 
655 9 |a electronic books  |2 eczenas 
776 0 8 |i Print version:  |z 3319550527  |z 9783319550527  |w (OCoLC)972251966 
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992 |c NTK-SpringerENG 
999 |c 100119  |d 100119 
993 |x NEPOSILAT  |y EIZ 

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