A novel magnetic solid-phase extraction method for detection of 14 heterocyclic aromatic amines by UPLC-MS/MS in meat products.

Bibliographic Details
Title: A novel magnetic solid-phase extraction method for detection of 14 heterocyclic aromatic amines by UPLC-MS/MS in meat products.
Authors: Shan S; School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China., Ma Y; School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China., Sun C; School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China., Guo X; School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China., Zheng H; School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China., Xu X; School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China; Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, China. Electronic address: xianbingxu@gmail.com., Qin L; School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China; Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, China., Hu J; School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China; Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, China. Electronic address: hujiangning2005@hotmail.com.
Source: Food chemistry [Food Chem] 2021 Feb 01; Vol. 337, pp. 127630. Date of Electronic Publication: 2020 Jul 27.
Publication Type: Journal Article
Language: English
Journal Info: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE
Imprint Name(s): Publication: Barking : Elsevier Applied Science Publishers
Original Publication: Barking, Eng., Applied Science Publishers.
MeSH Terms: Heterocyclic Compounds/*analysis , Meat Products/*analysis , Nanoparticles/*chemistry , Solid Phase Extraction/*methods, Amines/analysis ; Amines/chemistry ; Amines/isolation & purification ; Animals ; Carbolines/analysis ; Chromatography, Liquid ; Food Analysis/methods ; Heterocyclic Compounds/isolation & purification ; Imidazoles/analysis ; Indoles/chemistry ; Magnetic Phenomena ; Microscopy, Electron, Scanning ; Polymers/chemistry ; Pork Meat/analysis ; Quinolines/analysis ; Quinoxalines/analysis ; Solid Phase Extraction/instrumentation ; Spectroscopy, Fourier Transform Infrared ; Tandem Mass Spectrometry
Abstract: The current study developed a cheap and effective method for the simultaneous extraction of 14 heterocyclic aromatic amines (HAAs) in food matrix. Core-shell Fe 3 O 4 @PDA nanoparticles were constructed and acted as the magnetic solid-phase extraction adsorbent to separate and purify HAAs from meat products for the first time. Then, UPLC-MS/MS technique was employed to identify and quantify the HAAs easily. Fe 3 O 4 @PDA nanoparticles were synthesized and characterized successfully. Totally 14 HAAs were completely separated in 19.99 min with good regression coefficients. LODs and LOQs were in the range of 0.013-0.247 ng/g and 0.056-0.803 ng/g, respectively. The intra-day precisions and inter-day precisions were below 9%. Except for IQ[4,5-b], Phe-p-1, PhIP, other 11 types of HAAs (DMIP, 1,5,6-TMIP, IQ, IQx, MeIQ, MeIQx, 7,8-DiMeIQx, AαC, MeAαC, Harman, Norharman) could acquire relatively high recoveries (71.06%-108.49%). The proposed method was successfully devoted to the evaluation of HAAs levels in 8 commercial meat products to verify the adaptability.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
Contributed Indexing: Keywords: Fe(3)O(4)@PDA; Heterocyclic aromatic amines; Magnetic dispersive solid-phase extraction; Meat products; UPLC-MS/MS
Substance Nomenclature: 0 (Amines)
0 (Carbolines)
0 (Heterocyclic Compounds)
0 (Imidazoles)
0 (Indoles)
0 (Polymers)
0 (Quinolines)
0 (Quinoxalines)
0 (polydopamine)
20AI638WCJ (2-amino-3-methyl-9H-pyrido(2,3-b)indole)
77500-04-0 (2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline)
909C6UN66T (2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine)
94HMA1I78O (norharman)
G2Q7M1P33X (2-amino-3,4-dimethylimidazo(4,5-f)quinoline)
Entry Date(s): Date Created: 20200814 Date Completed: 20201130 Latest Revision: 20201130
Update Code: 20210623
DOI: 10.1016/j.foodchem.2020.127630
PMID: 32791432
Published: 2021 Feb 01
Database: MEDLINE

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